US 12,179,024 B2
Methods and systems for target localization and DBS therapy
Rosana Esteller, Santa Clarita, CA (US); Mahsa Malekmohammadi, Sherman Oaks, CA (US); Andrew Haddock, Los Angeles, CA (US); and Tianhe Zhang, Studio City, CA (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Oct. 9, 2023, as Appl. No. 18/483,265.
Application 18/483,265 is a continuation of application No. 17/653,814, filed on Mar. 7, 2022, granted, now 11,813,458.
Claims priority of provisional application 63/263,634, filed on Nov. 5, 2021.
Claims priority of provisional application 63/162,887, filed on Mar. 18, 2021.
Prior Publication US 2024/0033526 A1, Feb. 1, 2024
Int. Cl. A61N 1/05 (2006.01); A61N 1/36 (2006.01)
CPC A61N 1/3614 (2017.08) [A61N 1/0534 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of optimizing a position on an electrode lead implanted in a patient's brain for providing deep brain stimulation (DBS) to the patient's brain, the lead comprising a plurality of electrodes, the method comprising:
(a) determining an optimized stimulation waveform for evoking a detectable evoked potential by:
using one or more of the electrodes to provide an initial stimulation waveform, and
adjusting one or more parameters of the initial stimulation waveform until first evoked potentials are detectable using one or more of the electrodes,
(b) determining an optimized longitudinal stimulation position along an axis of the lead by:
providing stimulation at different longitudinal positions along the axis of the lead using the optimized stimulation waveform,
recording second evoked potentials evoked by the stimulation at each of the longitudinal positions,
comparing each of the second evoked potentials with each other, and
selecting the optimized longitudinal stimulation position based on the second evoked potentials, and
(c) determining an optimized rotational stimulation position about the axis of the lead by:
at the selected optimized longitudinal stimulation position providing stimulation at different rotational positions about the axis of the lead using the optimized stimulation waveform,
recording third evoked potentials evoked by the stimulation at each of the rotational positions, and
selecting the optimized rotational stimulation position based on the third evoked potential.