US 12,176,195 B2
Systems and methods of ion population regulation in mass spectrometry
Philip M. Remes, Livermore, CA (US); and Jesse D. Canterbury, Shoreline, WA (US)
Assigned to Thermo Finnigan LLC, San Jose, CA (US)
Filed by Thermo Finnigan LLC, San Jose, CA (US)
Filed on Jan. 15, 2024, as Appl. No. 18/412,911.
Application 18/412,911 is a division of application No. 17/745,780, filed on May 16, 2022, granted, now 11,908,670.
Prior Publication US 2024/0153751 A1, May 9, 2024
Int. Cl. H01J 49/00 (2006.01); G01N 30/72 (2006.01); G01N 30/86 (2006.01); G06N 3/08 (2023.01)
CPC H01J 49/0036 (2013.01) [G01N 30/7233 (2013.01); G01N 30/8675 (2013.01); G06N 3/08 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of performing mass spectrometry, comprising:
obtaining, based on a series of mass spectra of detected ions derived from components eluting from a chromatography column, a plurality of extracted ion chromatograms (XICs), each XIC comprising a plurality of detection points representing detected intensity for a distinct selected m/z as a function of time;
detecting, based on the series of mass spectra, precursor ions of each distinct selected m/z of the plurality of XICs; and
determining, for each XIC based on a set of detection points of the XIC, a predicted next detection point to be obtained based on a next mass spectrum to be acquired.