US 12,175,594 B2
Reduced order model for computing blood flow dynamics
Seyed Mehran Mirramezani, Albany, CA (US); and Shawn Shadden, Albany, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Appl. No. 17/621,645
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Jun. 26, 2020, PCT No. PCT/US2020/039765
§ 371(c)(1), (2) Date Dec. 21, 2021,
PCT Pub. No. WO2020/264259, PCT Pub. Date Dec. 30, 2020.
Claims priority of provisional application 62/867,041, filed on Jun. 26, 2019.
Prior Publication US 2022/0237864 A1, Jul. 28, 2022
Int. Cl. G06T 17/00 (2006.01); A61B 34/10 (2016.01); G06T 7/00 (2017.01); G06T 7/60 (2017.01)
CPC G06T 17/00 (2013.01) [A61B 34/10 (2016.02); G06T 7/0012 (2013.01); G06T 7/60 (2013.01); A61B 2034/105 (2016.02); G06T 2207/30048 (2013.01); G06T 2207/30104 (2013.01); G06T 2210/24 (2013.01); G06T 2210/41 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A computer-implemented method for non-invasive assessment of a patient's hemodynamics information, comprising:
generating, based on image data of the patient, a geometric model of at least one portion of a cardiovascular system of the patient;
determining, from the geometric model, one or more geometric features, the one or more geometric features including vessel length, one or more bifurcation angles, variation of cross-sectional area, and/or curvature along each of one or more vascular segments of the at least one portion of the cardiovascular system;
constructing a lumped parameter network (LPN) of resistors corresponding to the at least one portion of the cardiovascular system based on the one or more geometric features, wherein the LPN of resistors defines expected energy losses along the one or more vascular segments from viscous dissipation, unsteadiness, flow separation, vessel curvature, and/or vessel bifurcation; and
solving a system of equations corresponding to flow and pressure for the LPN in order to calculate a flow rate through each of the one or more vascular segments and pressure at one or more vascular junctions of the at least one portion of the cardiovascular system.