US 12,173,303 B2
Lettuce plant resistant to downy mildew and resistance gene
Bas Ter Riet, Enkhuizen (NL); Mathieu Andre Pel, Enkhuizen (NL); and Stephanie Melanie Broos, Enkhuizen (NL)
Assigned to Enza Zaden Beheer B.V., Enkhuizen (NL)
Appl. No. 17/414,142
Filed by Enza Zaden Beheer B.V., Enkhuizen (NL)
PCT Filed Dec. 4, 2019, PCT No. PCT/EP2019/083651
§ 371(c)(1), (2) Date Jun. 15, 2021,
PCT Pub. No. WO2020/126500, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. PCT/EP2018/085244 (WO), filed on Dec. 17, 2018.
Prior Publication US 2022/0090119 A1, Mar. 24, 2022
Int. Cl. C12N 15/82 (2006.01)
CPC C12N 15/8282 (2013.01) 14 Claims
OG exemplary drawing
 
1. A Lactuca sativa lettuce plant that is resistant to downy mildew caused by one or more of Bremia lactucae races B1:16, B1:20, B1:21, B1:23, and B1:27, comprising one or more mutations in a SL7 gene, wherein said SL7 gene encodes for a protein having the sequence of SEQ ID No. 2 or having at least 90% sequence identity with SEQ ID No. 2, wherein the one or more mutations in the SL7 gene comprise amino acid substitutions at positions 11, 38, 40, 48, 61, 69, 84, 91 and 129 corresponding to the SL7 protein sequence SEQ ID NO: 2.