US 12,173,263 B2
Organomimetic devices and methods of use and manufacturing thereof
Jose Fernandez-Alcon, Cambridge, MA (US); Norman Wen, Newton, MA (US); Richard Novak, Jamaica Plain, MA (US); Donald E. Ingber, Boston, MA (US); Geraldine A. Hamilton, Cambridge, MA (US); Christopher Hinojosa, Cambridge, MA (US); Karel Domansky, Charlestown, MA (US); Daniel Levner, Cambridge, MA (US); Guy Thompson, II, Lexington, MA (US); Kambez Hajipouran Benam, Cambridge, MA (US); Remi Villenave, Boston, MA (US); Thomas Umundum, Salzburg (AT); Alfred Paris, Salzburg (AT); and Georg Bauer, Salzburg (AT)
Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US)
Appl. No. 15/105,388
Filed by President and Fellows of Harvard College, Cambridge, MA (US); Jose Fernandez-Alcon, Cambridge, MA (US); Norman Wen, Newton, MA (US); and Richard Novak, Jamaica Plain, MA (US)
PCT Filed Dec. 19, 2014, PCT No. PCT/US2014/071570
§ 371(c)(1), (2) Date Jun. 16, 2016,
PCT Pub. No. WO2015/138032, PCT Pub. Date Sep. 17, 2015.
Claims priority of provisional application 61/919,181, filed on Dec. 20, 2013.
Prior Publication US 2016/0326477 A1, Nov. 10, 2016
Int. Cl. C12M 3/06 (2006.01); B01D 61/18 (2006.01); B01D 63/08 (2006.01); B01D 67/00 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 1/34 (2006.01); C12M 1/42 (2006.01); C12M 3/00 (2006.01)
CPC C12M 23/16 (2013.01) [B01D 61/18 (2013.01); B01D 63/081 (2013.01); B01D 67/0023 (2013.01); B01L 3/5027 (2013.01); B01L 3/502753 (2013.01); C12M 21/08 (2013.01); C12M 23/26 (2013.01); C12M 25/02 (2013.01); C12M 35/04 (2013.01); C12M 41/00 (2013.01); C12M 41/46 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0887 (2013.01); B01L 2400/0487 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A microfluidic device comprising:
a) a central microchannel having a longitudinal axis, an inlet port, an outlet port, and a plurality of cut-outs that extend transverse to said longitudinal axis of said central microchannel, said plurality of cut-outs are not fluidically connected to said central microchannel, and are positioned between said inlet and said outlet ports; and
b) a plurality of opposing connection elements fastened to a first and opposing second location of said microfluidic device, said opposing connection elements physically connected to a mechanical stretch actuator configured to impart motion that is transferred to a portion of the microfluidic device between said first location and the opposing second location.