US 12,173,035 B2
Polynucleotides and polypeptides useful for making alkaloid compounds
Peter James Facchini, Calgary (CA); and Joseph E. Tucker, Strathmore (CA)
Assigned to Antheia, Inc., Menlo Park, CA (US)
Filed by Antheia, Inc., Menlo Park, CA (US)
Filed on Oct. 20, 2022, as Appl. No. 18/048,298.
Application 18/048,298 is a continuation of application No. 16/312,895, granted, now 11,479,586, previously published as PCT/CA2017/050779, filed on Jun. 27, 2017.
Claims priority of provisional application 62/355,022, filed on Jun. 27, 2016.
Claims priority of provisional application 62/433,431, filed on Dec. 13, 2016.
Claims priority of provisional application 62/514,104, filed on Jun. 2, 2017.
Prior Publication US 2023/0303639 A1, Sep. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/415 (2006.01); C12N 9/00 (2006.01); C12N 15/52 (2006.01); C12N 15/79 (2006.01); C12N 15/80 (2006.01); C12N 15/81 (2006.01); C12N 15/82 (2006.01); C12P 17/12 (2006.01); C12P 17/18 (2006.01)
CPC C07K 14/415 (2013.01) [C12N 9/00 (2013.01); C12N 15/52 (2013.01); C12N 15/80 (2013.01); C12N 15/81 (2013.01); C12N 15/8261 (2013.01); C12P 17/12 (2013.01); C12P 17/18 (2013.01)] 18 Claims
 
1. A composition comprising an engineered non-plant cell that contains a polynucleotide encoding a polypeptide having thebaine synthase activity that is at least 70% identical to the amino acid sequence of SEQ ID NO:29 or SEQ ID NO:900.