US 12,172,991 B2
Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof
Arindam Talukdar, Kolkata (IN); Benu Brata Das, Kolkata (IN); Biswajit Kundu, Kolkata (IN); Subhendu K. Das, Kolkata (IN); Chowdhuri Srijita Paul, Kolkata (IN); Dipayan Sarkar, Kolkata (IN); Sourav Pal, Kolkata (IN); Debomita Bhattacharya, Kolkata (IN); Ayan Mukherjee, Kolkata (IN); and Subhajit Roy, Kolkata (IN)
Assigned to Council of Scientific & Industrial Research, New Delhi (IN); and Indian Association for the Cultivation of Science, Kolkata (IN)
Appl. No. 17/059,289
Filed by Council of Scientific & Industrial Research, New Delhi (IN); and Indian Association for the Cultivation of Science, Kolkat (IN)
PCT Filed May 24, 2019, PCT No. PCT/IN2019/050410
§ 371(c)(1), (2) Date Nov. 27, 2020,
PCT Pub. No. WO2019/229765, PCT Pub. Date Dec. 5, 2019.
Claims priority of application No. 201811020003 (IN), filed on May 29, 2018.
Prior Publication US 2021/0246128 A1, Aug. 12, 2021
Int. Cl. C07D 413/14 (2006.01); C07D 413/04 (2006.01); C07D 491/22 (2006.01)
CPC C07D 413/14 (2013.01) [C07D 413/04 (2013.01); C07D 491/22 (2013.01)] 12 Claims
 
1. A compound of Formula I or salts thereof,

OG Complex Work Unit Chemistry
wherein:
R1 is a substituted aromatic heterocyclic group selected from the group consisting of oxadiazole, pyridyl, amino pyridyl, and furyl, wherein the aromatic heterocyclic group is substituted with —CH3 or —NH2;
R2 is a water soluble or hydrophilic functional group —NR5R6;
R5 and R6 are either same or different selected from hydrogen atom, a substituted C1-C6 alkyl chain bearing nitrogen containing aromatic heterocyclic group, or a substituted C1-C6 alkyl chain bearing nitrogen containing aliphatic heterocyclic group;
R3 is selected from hydrogen, halogen, hydroxy, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, amino, alkylamino, acyl amino, or carbamate;
X is CH; and
n is 0-3.