US 12,172,946 B2
Compound containing diphenylmethane structure and use thereof
Weizhou Liang, Guangzhou (CN); Qingquan Zheng, Guangzhou (CN); and Qi Tang, Guangzhou (CN)
Assigned to GUANGZHOU TROJAN PHARMATEC LTD., Guangdong (CN)
Appl. No. 17/421,316
Filed by GUANGZHOU TROJAN PHARMATEC LTD., Guangdong (CN)
PCT Filed Dec. 13, 2019, PCT No. PCT/CN2019/125136
§ 371(c)(1), (2) Date Jul. 7, 2021,
PCT Pub. No. WO2020/143392, PCT Pub. Date Jul. 16, 2020.
Claims priority of application No. 201910012866.7 (CN), filed on Jan. 7, 2019.
Prior Publication US 2022/0002230 A1, Jan. 6, 2022
Int. Cl. C07C 235/60 (2006.01); C07C 233/18 (2006.01); C07C 233/22 (2006.01); C07C 233/47 (2006.01); C07C 235/34 (2006.01); C07C 235/50 (2006.01); C07C 235/52 (2006.01); C07K 1/06 (2006.01)
CPC C07C 235/60 (2013.01) [C07C 233/18 (2013.01); C07C 233/22 (2013.01); C07C 233/47 (2013.01); C07C 235/34 (2013.01); C07C 235/50 (2013.01); C07C 235/52 (2013.01); C07K 1/061 (2013.01)] 19 Claims
 
1. A compound containing a diphenylmethane structure, wherein a structure of the compound is as shown in General Formula (1):

OG Complex Work Unit Chemistry
wherein,
X is selected from OH, halogen or NHRa, and Ra is selected from hydrogen, alkyl group or aralkyl group;
Y is selected from hydrogen, phenyl group or halogenated phenyl group;
ring A and ring B may contain a substituent selected from halogen atom, C1-C5 alkyl group substituted with halogen atom, C1-C5 alkyl group unsubstituted with halogen atom, C1-C5 alkoxy group substituted with halogen atom, or C1-C5 alkoxy group unsubstituted with halogen atom, in addition to the RQ substituent;
Q is independently selected from O, NH, NHCO, CO, CONH, S, SO or SO2;
n1 and n2 represents an integer of 0-3, respectively, and n1 and n2 are not 0 at the same time;
R is independently selected from a group represented by General Formula (2):

OG Complex Work Unit Chemistry
in the General Formula (2), * represents connected with Q;
R1 is selected from a C1-C25 alkyl group or a group represented by General Formula (3):

OG Complex Work Unit Chemistry
in the General Formula (3), * represents connected with carbonyl;
m represents an integer of 1-3;
R3 is selected from C6-C25 alkyl group, and a total carbon number of m R3 is not less than 8;
k represents an integer of 0-3;
ring C may contain a substituent selected from halogen atom, C1-C5 alkyl group substituted with halogen atom, C1-C5 alkyl group unsubstituted with halogen atom, C1-C5 alkoxy group substituted with halogen atom, C1-C5 alkoxy group unsubstituted with halogen atom, in addition to the m R3O substituents;
R2 is selected from hydrogen, C1-C25 alkyl group or a group represented by General Formula (4):

OG Complex Work Unit Chemistry
in the General Formula (4), * represents connected with N; m2 represents an integer of 0-3;
R7 is selected from C6-C25 alkyl group;
k7 represents an integer of 1-6;
ring D may contain a substituent selected from halogen atom, C1-C5 alkyl group substituted with halogen atom, C1-C5 alkyl group unsubstituted with halogen atom, C1-C5 alkoxy group substituted with halogen atom, C1-C15 alkoxy group unsubstituted with halogen atom, in addition to the m2 R7O substituents;
L is selected from C2-C15 organic chain group containing O, N or S heteroatoms, or C2-C15 organic chain group not containing O, N or S heteroatoms, and when L is selected from the C2-C15 organic chain group not containing O, N or S heteroatoms, R2≠H.