US 12,171,904 B2
Mineral coated scaffolds
Leenaporn Jongpaiboonkit, Madison, WI (US); and William L. Murphy, Madison, WI (US)
Assigned to TRS Holdings LLC, Ann Arbor, MI (US)
Filed by TRS Holdings LLC, Ann Arbor, MI (US)
Filed on Aug. 25, 2020, as Appl. No. 17/002,482.
Application 17/002,482 is a continuation of application No. 14/637,345, filed on Mar. 3, 2015, granted, now 10,772,987.
Application 14/637,345 is a continuation in part of application No. 13/036,470, filed on Feb. 28, 2011, abandoned.
Application 13/036,470 is a continuation in part of application No. 11/927,322, filed on Oct. 29, 2007, granted, now 9,439,948, issued on Sep. 13, 2016.
Application 14/637,345 is a continuation in part of application No. 13/879,178, granted, now 11,607,391, previously published as PCT/US2009/058419, filed on Sep. 25, 2009.
Application 14/637,345 is a continuation in part of application No. 13/407,441, filed on Feb. 28, 2012, granted, now 9,943,410, issued on Apr. 17, 2018.
Claims priority of provisional application 61/447,352, filed on Feb. 28, 2011.
Claims priority of provisional application 61/100,062, filed on Sep. 25, 2008.
Claims priority of provisional application 60/855,235, filed on Oct. 30, 2006.
Prior Publication US 2020/0384154 A1, Dec. 10, 2020
Int. Cl. A61L 27/32 (2006.01); A61F 2/44 (2006.01); A61K 38/18 (2006.01); A61K 38/30 (2006.01); A61L 27/18 (2006.01); A61L 27/56 (2006.01); A61F 2/28 (2006.01); A61F 2/30 (2006.01)
CPC A61L 27/32 (2013.01) [A61F 2/4455 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/1858 (2013.01); A61K 38/1875 (2013.01); A61K 38/30 (2013.01); A61L 27/18 (2013.01); A61L 27/56 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/30011 (2013.01); A61F 2002/30032 (2013.01); A61F 2002/30056 (2013.01); A61F 2002/30062 (2013.01); A61F 2002/30064 (2013.01); A61F 2002/3008 (2013.01); A61F 2002/30303 (2013.01); A61F 2002/30578 (2013.01); A61F 2002/30785 (2013.01); A61F 2002/30789 (2013.01); A61F 2002/30838 (2013.01); A61F 2002/30878 (2013.01); A61F 2002/30884 (2013.01); A61F 2002/30892 (2013.01); A61F 2002/30899 (2013.01); A61F 2002/3092 (2013.01); A61F 2002/4485 (2013.01); A61F 2210/0004 (2013.01); A61F 2310/00017 (2013.01); A61F 2310/00023 (2013.01); A61F 2310/00029 (2013.01); A61F 2310/00089 (2013.01); A61F 2310/00113 (2013.01); A61F 2310/00131 (2013.01); A61F 2310/00149 (2013.01); A61F 2310/00155 (2013.01); A61F 2310/00293 (2013.01); A61F 2310/00796 (2013.01); A61F 2310/0097 (2013.01); A61F 2310/00976 (2013.01); A61L 2400/18 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01); A61L 2430/02 (2013.01); A61L 2430/38 (2013.01)] 3 Claims
 
1. A mineral coated scaffold comprising a matrix material, wherein the mineral coating comprises a carbonate-substituted, calcium-deficient hydroxyapatite component; and wherein the mineral coating comprises about 97% hydroxyapatite and about 3% octacalcium phosphate, the mineral coating has about 90% to about 100% crystallinity, a porosity between about 20% and about 28% and a plate-like nanostructure.