US 12,171,884 B2
Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
Andre E. Nel, Sherman Oaks, CA (US); Huan Meng, Los Angeles, CA (US); and Xiangsheng Liu, Los Angeles, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Jul. 23, 2021, as Appl. No. 17/384,214.
Application 17/384,214 is a continuation of application No. 16/947,539, filed on Aug. 5, 2020, granted, now 11,096,900.
Application 16/947,539 is a continuation of application No. 16/164,030, filed on Oct. 18, 2018, granted, now 10,765,636, issued on Sep. 8, 2020.
Application 16/164,030 is a continuation of application No. 15/798,287, filed on Oct. 30, 2017, granted, now 10,143,660, issued on Dec. 4, 2018.
Application 15/798,287 is a continuation of application No. PCT/US2017/012625, filed on Jan. 6, 2017.
Claims priority of provisional application 62/276,634, filed on Jan. 8, 2016.
Prior Publication US 2022/0160644 A1, May 26, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/51 (2006.01); A61K 9/127 (2006.01); A61K 31/4745 (2006.01); A61K 45/06 (2006.01); A61K 47/62 (2017.01); A61K 47/69 (2017.01); A61K 9/00 (2006.01)
CPC A61K 9/5115 (2013.01) [A61K 9/127 (2013.01); A61K 9/5123 (2013.01); A61K 9/5192 (2013.01); A61K 31/4745 (2013.01); A61K 45/06 (2013.01); A61K 47/62 (2017.08); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); A61K 9/0019 (2013.01); A61K 9/1278 (2013.01); Y10S 977/773 (2013.01); Y10S 977/906 (2013.01); Y10S 977/907 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method of making a drug nanocarrier, comprising:
providing a nanocarrier comprising a silica body having a surface including a plurality of pores suitable to receive molecules therein, disposing a cargo trapping agent within the plurality of pores;
coating the plurality of pores of the nanocarrier with a phospholipid bilayer, wherein the phospholipid bilayer encapsulates said silica body and seals the plurality of pores; and
introducing a cargo comprising a drug into the plurality of pores, so that a phospholipid bilayer coated drug nanocarrier is made, wherein the nanocarrier shows <5% drug leakage over 24 hours in a biological buffer with pH of 7.4 at 37° C.