US 12,171,879 B2
Articles and methods for administration of therapeutic agents
Carlo Giovanni Traverso, Newton, MA (US); Joshua Korzenik, Waban, MA (US); Robert S. Langer, Newton, MA (US); and Christoph Winfried Johannes Steiger, Cambridge, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed on Jan. 6, 2022, as Appl. No. 17/569,881.
Application 17/569,881 is a continuation of application No. 16/991,536, filed on Aug. 12, 2020, abandoned.
Claims priority of provisional application 62/885,450, filed on Aug. 12, 2019.
Prior Publication US 2022/0202721 A1, Jun. 30, 2022
Int. Cl. A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 9/48 (2006.01)
CPC A61K 9/2054 (2013.01) [A61K 9/2013 (2013.01); A61K 9/2846 (2013.01); A61K 9/2866 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 9/4891 (2013.01)] 20 Claims
 
1. An article, comprising:
a first portion comprising a first bile acid salt, wherein the first portion is an immediate release layer, wherein the first bile acid salt is present in the first portion in an amount greater than or equal to 100 milligrams and less than or equal to 2 grams; and
a second portion adjacent to the first portion, the second portion comprising a second bile acid salt, wherein the second portion is an extended release layer, wherein the second bile acid salt is present in the second portion in an amount greater than or equal to 100 milligrams and less than or equal to 2 grams,
wherein the first bile acid salt comprises sodium chenodeoxycholate,
wherein the second bile acid salt comprises sodium chenodeoxycholate, and
wherein the first and second bile acid salts are present in different amounts and the total amount of bile acid salt in the first portion and the second portion is greater than or equal to 80 wt % and less than or equal to 98 wt % versus the total weight of the first portion and second portion.