US 12,171,603 B2
Renal denervation ablation monitoring using perfusion angiography
Bart Carelsen, Eindhoven (NL); Jim Reekers, Eindhoven (NL); Iris Ter Horst, Eindhoven (NL); and Arjen Van Der Horst, Tilburg (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/768,099
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Sep. 29, 2020, PCT No. PCT/EP2020/077157
§ 371(c)(1), (2) Date Apr. 11, 2022,
PCT Pub. No. WO2021/073862, PCT Pub. Date Apr. 22, 2021.
Claims priority of application No. 19202890 (EP), filed on Oct. 14, 2019.
Prior Publication US 2024/0081758 A1, Mar. 14, 2024
Int. Cl. A61B 6/00 (2024.01); A61B 90/00 (2016.01)
CPC A61B 6/481 (2013.01) [A61B 6/487 (2013.01); A61B 6/5217 (2013.01); A61B 90/37 (2016.02); A61B 2090/376 (2016.02)] 16 Claims
OG exemplary drawing
 
1. An apparatus for providing treatment guidance for an ablation treatment, comprising:
an input unit adapted to receive:
a first time series of diagnostic images of a region of interest of a patient's vasculature, the first time series representing a first state, wherein the first state corresponds to a post-treatment state specific to the patient; and
a second time series of a reference vasculature different than the patient's vasculature, the second time series representing a second state, wherein the second state comprises successful renal denervation treatment state that is not specific to the patient;
a processing unit adapted to:
derive, from the first time series of diagnostic images, a first dynamics measure indicative of a contrast agent dynamic through the region of interest over time for the first state; and
determine at least one index indicative of a relative difference between the first state and the second state, wherein the at least one index is determined using:
the first dynamics measure; and
a second dynamics measure based on the second time series and indicative
of a contrast agent dynamic over time for the second state; and
an output unit adapted to output the at least one index to a user.