US 11,852,605 B2
Metal-organic frameworks for electrochemical detection of analytes
Katherine A. Mirica, Hanover, NH (US); Lukasz K. Mendecki, White River Junction, VT (US); Michael Ko, West Lebanon, NH (US); Zheng Meng, West Lebanon, NH (US); Robert M. Stolz, Lyme, NH (US); and Aileen Eagleton, Hanover, NH (US)
Assigned to Trustees of Dartmouth College, Hanover, NH (US)
Appl. No. 17/252,003
Filed by Trustees of Dartmouth College, Hanover, NH (US)
PCT Filed Jun. 21, 2019, PCT No. PCT/US2019/038492
§ 371(c)(1), (2) Date Dec. 14, 2020,
PCT Pub. No. WO2020/055474, PCT Pub. Date Mar. 19, 2020.
Claims priority of provisional application 62/688,261, filed on Jun. 21, 2018.
Prior Publication US 2021/0262970 A1, Aug. 26, 2021
Int. Cl. G01N 27/327 (2006.01); C07F 1/08 (2006.01); C07F 15/00 (2006.01); C07F 15/04 (2006.01); C07F 15/06 (2006.01); B82Y 30/00 (2011.01); B82Y 35/00 (2011.01); B82Y 40/00 (2011.01)
CPC G01N 27/3278 (2013.01) [C07F 1/08 (2013.01); C07F 15/006 (2013.01); C07F 15/04 (2013.01); C07F 15/06 (2013.01); G01N 27/3277 (2013.01); B82Y 30/00 (2013.01); B82Y 35/00 (2013.01); B82Y 40/00 (2013.01); G01N 2333/575 (2013.01)] 21 Claims
 
1. A method of detecting an analyte in a sample, said method comprising:
associating the sample with an electrode,
wherein the electrode comprises a metal-organic framework,
wherein the metal-organic framework comprises one or more metals and one or more ligands coordinated with the one or more metals, wherein the one or more ligands comprise triphenylene-based ligands, wherein the triphenylene-based ligands are selected from the group consisting of 2,3,5,6,10,11-hexahydroxytriphenylene (HHTP), 2,3,5,6,10,11-hexaiminotriphenylene (HITP), 2,3,5,6,10,11-hexathiotriphenylene (HTTP), and combinations thereof; and
evaluating the redox properties of the electrode,
wherein the redox properties are selected from the group consisting of oxidation, reduction, redox potential, and combinations thereof; and
correlating the redox properties of the electrode to the presence or absence of the analyte in the sample.