US 11,852,459 B2
Method and device for superresolution optical measurement using singular optics
Gabriel Y Sirat, Paris (FR)
Assigned to Bioaxial SAS, Paris (FR)
Filed by Bioaxial, SAS, Paris (FR)
Filed on Mar. 6, 2023, as Appl. No. 18/179,062.
Application 18/179,062 is a continuation of application No. 17/589,265, filed on Jan. 31, 2022, granted, now 11,598,630.
Application 17/589,265 is a continuation of application No. 17/087,238, filed on Nov. 2, 2020, granted, now 11,236,992, issued on Feb. 1, 2022.
Application 17/087,238 is a continuation of application No. 16/557,030, filed on Aug. 30, 2019, granted, now 10,823,551, issued on Nov. 3, 2020.
Application 16/557,030 is a continuation of application No. 15/812,016, filed on Nov. 14, 2017, granted, now 10,401,153, issued on Sep. 3, 2019.
Application 15/812,016 is a continuation of application No. 14/998,051, filed on Dec. 24, 2015, granted, now 9,846,030, issued on Dec. 19, 2017.
Application 14/998,051 is a continuation of application No. 13/822,355, granted, now 9,250,185, issued on Feb. 2, 2016, previously published as PCT/FR2013/000555, filed on Mar. 12, 2013.
Claims priority of application No. 1004067 (FR), filed on Oct. 15, 2010.
Prior Publication US 2023/0228561 A1, Jul. 20, 2023
Int. Cl. G01B 11/14 (2006.01); G01N 21/64 (2006.01); G02B 21/00 (2006.01); G02B 21/16 (2006.01); G01B 11/25 (2006.01)
CPC G01B 11/14 (2013.01) [G01N 21/64 (2013.01); G01N 21/6428 (2013.01); G01N 21/6458 (2013.01); G02B 21/0056 (2013.01); G02B 21/0072 (2013.01); G02B 21/0076 (2013.01); G02B 21/16 (2013.01); G01B 11/25 (2013.01); G01N 2201/06113 (2013.01); G01N 2201/12 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method for measuring a position of a fluorophore, the method comprising:
configuring a set of compact light distributions, the set having at least one member, each light distribution characterized by a center, so that there is substantially zero intensity at the center of the set of compact light distributions;
moving the set of compact light distributions in relation to a set of hypothesized positions of the fluorophore;
detecting, in a plurality of locations corresponding to the hypothesized set of positions, a set of images; and
estimating the position of the fluorophore, by determining from the set of images a set of parameters describing the position of the fluorophore using an inverse problem method.