US 11,851,649 B2
Generating mammalian T cell activation inducible synthetic promoters (SYN+PRO) to improve T cell therapy
Jia Wei, Redmond, WA (US); and Michael C. Jensen, Bainbridge Island, WA (US)
Assigned to Seattle Children's Hospital, Seattle, WA (US)
Appl. No. 16/613,025
Filed by Seattle Children's Hospital, Seattle, WA (US)
PCT Filed May 15, 2018, PCT No. PCT/US2018/032800
§ 371(c)(1), (2) Date Nov. 12, 2019,
PCT Pub. No. WO2018/213332, PCT Pub. Date Nov. 22, 2018.
Claims priority of provisional application 62/507,565, filed on May 17, 2017.
Prior Publication US 2020/0095573 A1, Mar. 26, 2020
Int. Cl. A61K 39/00 (2006.01); C12N 5/06 (2006.01); C12N 15/10 (2006.01)
CPC C12N 15/1051 (2013.01) 20 Claims
 
1. An isolated nucleic acid comprising a promoter comprising a transcription response element having a sequence with at least 98% sequence identity to the sequence as set forth in SEQ ID NO: 7.