	US 11,851,489 B2
	Heterodimerizing Ig domains
Fabian Richter, Kirchheim Unter Teck (DE); Oliver Seifert, Stuttgart (DE); and Roland Kontermann, Nürtingen (DE)
Assigned to UNIVERSITÄT STUTTGART, Stuttgart (DE)
Appl. No. 16/615,536
Filed by UNIVERSITÄT STUTTGART, Stuttgart (DE)
PCT Filed Jun. 1, 2018, PCT No. PCT/EP2018/064538 § 371(c)(1), (2) Date Nov. 21, 2019, PCT Pub. No. WO2018/220216, PCT Pub. Date Dec. 6, 2018.
Claims priority of application No. 17174087 (EP), filed on Jun. 1, 2017.
Prior Publication US 2020/0172619 A1, Jun. 4, 2020
Int. Cl. C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C07K 16/40 (2006.01); A61K 38/00 (2006.01)

CPC C07K 16/2809 (2013.01) [C07K 16/2878 (2013.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/528 (2013.01); C07K 2317/53 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01)]

6 Claims

1. A protein complex comprising at least two amino acid chains I and II, which are non-covalently bound to each other through a heterodimerization region I (HRI) comprised in amino acid chain I and a heterodimerization region II (HRII) comprised in amino acid chain II, wherein HRI and HRII have the amino acid sequence according to SEQ ID NO: 20 and 21 respectively, or a heterodimerizing variant thereof having at least 97.5% sequence identity to the respectively indicated amino acid sequence.