CPC C07K 14/70521 (2013.01) [A61K 9/5068 (2013.01); A61K 47/42 (2013.01); A61P 29/00 (2018.01); C07K 14/70503 (2013.01); C07K 14/70532 (2013.01); C07K 14/70596 (2013.01); A61K 38/00 (2013.01); C07K 2319/03 (2013.01)] | 14 Claims |
1. A composition comprising a plurality of extracellular vesicles, wherein an extracellular vesicle of the plurality of extracellular vesicles comprises a first immune checkpoint moiety and a second immune checkpoint moiety,
wherein the first immune checkpoint moiety is CD200 and the second immune checkpoint moiety is an extracellular domain of PD-L1,
said extracellular domain of PD-L1 is linked to a transmembrane moiety of the extracellular vesicle,
said transmembrane moiety is different from said second immune checkpoint moiety, and
wherein the second immune checkpoint moiety is exposed on a surface of said extracellular vesicle.
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