CPC C07D 487/04 (2013.01) [C07D 498/04 (2013.01)] | 17 Claims |
1. A compound of Formula I:
or a pharmaceutically acceptable salt, deuterated analog, stereoisomer, mixture of stereoisomers, tautomer, or prodrug thereof, wherein:
X is CR4, wherein R4 is H or optionally substituted alkyl;
Cy is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
Y1 and Y3 are independently CR5R6;
Y2 is O;
R1 is cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, —SR8, —SOR8, —SO2R8, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
or R1 and Y3 together form an optionally substituted heterocyclyl;
R2 is cyano, hydrogen, halo, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; or R1 and R2 together form an optionally substituted cycloalkyl or optionally substituted heterocyclyl;
each R3 is independently halo, cyano, or optionally substituted alkyl; or two R3 together form an optionally substituted cycloalkyl or an optionally substituted heterocyclyl;
R5 and R6 are independently cyano, halo, hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, —SH, —SR8, —SOR8, —SO2R8, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; or R5 and R6 together with the carbon atom to which they are both attached form an optionally substituted cycloalkyl, optionally substituted heterocyclyl, or oxo; or any two R5 groups attached to adjacent carbon atoms together form an optionally substituted cycloalkyl or optionally substituted heterocyclyl;
R7 is hydrogen or optionally substituted alkyl;
R8 is optionally substituted alkyl; and
n is 0, 1, 2, 3, 4, or 5.
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