US 11,851,428 B2
Activator of TREK (TWIK RElated K+channels) channels
Craig W. Lindsley, Brentwood, TN (US); Joshua M. Wieting, Brentwood, TN (US); Kevin M. Mcgowan, Nashville, TN (US); Jerod S. Denton, Nashville, TN (US); Kentaro Yashiro, Osaka (JP); Haruto Kurata, Osaka (JP); Yoko Sekioka, Osaka (JP); Takahiro Mori, Osaka (JP); and Yuzo Iwaki, Osaka (JP)
Assigned to ONO PHARMACEUTICAL CO., LTD., Osaka (JP); and VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed by ONO PHARMACEUTICAL CO., LTD., Osaka (JP); and VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed on May 24, 2021, as Appl. No. 17/328,814.
Application 17/328,814 is a division of application No. 16/470,196, granted, now 11,046,683, previously published as PCT/JP2017/044975, filed on Dec. 14, 2017.
Claims priority of provisional application 62/434,524, filed on Dec. 15, 2016.
Prior Publication US 2021/0347773 A1, Nov. 11, 2021
Int. Cl. C07D 213/36 (2006.01); C07D 231/12 (2006.01); C07D 249/08 (2006.01); C07D 401/04 (2006.01); A61K 31/454 (2006.01); C07D 471/04 (2006.01); C07C 255/57 (2006.01); C07C 317/28 (2006.01); C07D 209/30 (2006.01); C07D 213/89 (2006.01); C07D 231/56 (2006.01); C07D 235/16 (2006.01); C07D 237/24 (2006.01); C07D 239/47 (2006.01); C07D 249/18 (2006.01); C07D 257/04 (2006.01); C07D 265/36 (2006.01); C07D 271/10 (2006.01); C07D 285/14 (2006.01); C07D 295/04 (2006.01); C07D 513/04 (2006.01)
CPC C07D 471/04 (2013.01) [C07C 255/57 (2013.01); C07C 317/28 (2013.01); C07D 209/30 (2013.01); C07D 213/89 (2013.01); C07D 231/56 (2013.01); C07D 235/16 (2013.01); C07D 237/24 (2013.01); C07D 239/47 (2013.01); C07D 249/08 (2013.01); C07D 249/18 (2013.01); C07D 257/04 (2013.01); C07D 265/36 (2013.01); C07D 271/10 (2013.01); C07D 285/14 (2013.01); C07D 295/04 (2013.01); C07D 401/04 (2013.01); C07D 513/04 (2013.01)] 4 Claims
 
1. A compound of formula (Id-1-1):

OG Complex Work Unit Chemistry
wherein
E is —C(O)NR1—;
R1 is hydrogen, or C1-C4-alkyl;
R4-d is halo, SF5, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, or C1-C4-haloalkylthio;

OG Complex Work Unit Chemistry
is

OG Complex Work Unit Chemistry
wherein arrow represents connecting position with E, each ring corresponding to ring C may be substituted independently with 1 to 3 R9 groups which is selected from halogen, hydroxyl, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, or C1-C4-haloalkoxy, each ring corresponding to ring D may be substituted independently with 1 to 3 R10 groups which is selected from halogen, hydroxyl, oxo, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, or C1-C4-haloalkoxy,
or
a pharmaceutically acceptable salt thereof.