US 11,850,451 B2
Cosmetic compositions and methods for improving skin conditions
Alfred Schmidt, Nambsheim (FR)
Assigned to Lucolas-M.D. Ltd., Birmingham (GB)
Filed by Lucolas-M.D. Ltd., Birmingham (GB)
Filed on Aug. 4, 2020, as Appl. No. 16/984,721.
Application 16/984,721 is a continuation in part of application No. 16/710,517, filed on Dec. 11, 2019, abandoned.
Application 16/710,517 is a continuation of application No. 13/982,539, abandoned, previously published as PCT/EP2012/051421, filed on Jan. 30, 2012.
Claims priority of provisional application 61/444,795, filed on Feb. 21, 2011.
Claims priority of application No. 10 2011 003 408.0 (DE), filed on Jan. 31, 2011.
Prior Publication US 2020/0360734 A1, Nov. 19, 2020
Int. Cl. A61Q 19/00 (2006.01); A61K 8/49 (2006.01); A61K 8/73 (2006.01); A61Q 19/08 (2006.01); A61Q 19/06 (2006.01); A61K 8/63 (2006.01); A61K 8/9789 (2017.01); A61K 8/97 (2017.01)
CPC A61Q 19/00 (2013.01) [A61K 8/49 (2013.01); A61K 8/4986 (2013.01); A61K 8/63 (2013.01); A61K 8/735 (2013.01); A61K 8/97 (2013.01); A61K 8/9789 (2017.08); A61Q 19/06 (2013.01); A61Q 19/08 (2013.01)] 13 Claims
 
1. A method for improving a general condition and appearance of skin, the method comprising treating a patient for cosmetic purposes with a composition comprising the following active ingredients:
an aromatase inhibitor and a 5-α-reductase inhibitor,
an antioxidant, and
hyaluronic acid;
wherein
the aromatase inhibitor is a steroidal aromatase-inactivator; the 5-α-reductase inhibitor is selected from the group consisting of an extract from the fruit of saw palmetto (Serenoa repens, syn. Sabal serrulata), an extract from the root of stinging nettle (Urtica dioica), a bark extract of Pygeum africanium, and an extract from pumpkin seed (Cucurbita pepo seed);
the antioxidant is an α-lipoic acid or a green tea extract, wherein the green tea extract contains polyphenols;
the aromatase inhibitor is present in the composition in a concentration from 0.25 weight-% to 1.8 weight-%;
the 5-α-reductase inhibitor is present in the composition in a concentration from 0.5 weight-% to 5 weight-%; and
the antioxidant is present in the composition in a concentration from 0.2 weight-% to 2.5 weight-%;
wherein the composition is administered topically to the skin;
and wherein the method comprises:
a) administering 20 ng/g skin tissue to 40 ng/g skin tissue of the 5-α-reductase inhibitor to the patient,
b) administering 25 ng/g skin tissue to 45 ng/g skin tissue of the steroidal aromatase inhibitor to the patient, or
c) administering 25 ng/g skin tissue to 40 ng/g skin tissue of the antioxidant to the patient.