US 11,850,419 B2
Implantable electrode arrangement
Dennis Plachta, Voerstetten (DE); Mortimer Giehrtmuehlen, Freiburg (DE); Thomas Stieglitz, Freiburg (DE); and Josef Zentner, Freiburg (DE)
Assigned to NEUROLOOP GMBH, Freiburg (DE)
Appl. No. 15/517,903
Filed by Neuroloop GmbH, Freiburg (DE)
PCT Filed Oct. 7, 2015, PCT No. PCT/EP2015/073129
§ 371(c)(1), (2) Date Apr. 7, 2017,
PCT Pub. No. WO2016/055512, PCT Pub. Date Apr. 14, 2016.
Claims priority of application No. 102014014927.7 (DE), filed on Oct. 7, 2014.
Prior Publication US 2017/0319846 A1, Nov. 9, 2017
Int. Cl. A61N 1/05 (2006.01); A61B 5/24 (2021.01)
CPC A61N 1/0556 (2013.01) [A61B 5/24 (2021.01); A61B 2562/066 (2013.01); A61B 2562/164 (2013.01)] 32 Claims
OG exemplary drawing
 
1. An implantable electrode arrangement for treating hypertension by spatially selective directional detection and manipulating of neuronal electrical signals, which propagate along at least one baroreceptive nerve fiber contained in a nerve bundle, and which when implanted provides selective overwriting of the at least one baroreceptive nerve fiber leading to the brain and also provides selective blocking of the at least one nerve fiber leading to the heart, comprising:
a biocompatible carrier substrate, including at least one carrier substrate region, comprising a cuff which is configured to be placed around the nerve bundle when implanted, and having a cylindrical carrier substrate which is configured when implanted to be oriented to face the nerve bundle, and a circumferential and axial extension;
a first electrode arrangement attached to the biocompatible carrier substrate including at least three axially spaced first electrode structures each comprising at least two first circumferential electrode surfaces, at least two separated axial first electrode strips which are configurable when implanted to assume a ring shape surrounding the nerve bundle to axially enclose the at least three first electrode structures on both sides, and the first electrode arrangement being connectable or connected to a signal detector and to a signal generator and configured when implanted to spatially selectively directionally detect the neuronal signals which propagate along the at least one baroreceptive nerve fiber leading to the brain contained in the nerve bundle and means configured when implanted for selectively overwriting the neuronal signals flowing along at least one baroreceptive nerve fiber leading to the brain to provide the stimulation of the selected at least one baroreceptive nerve fiber leading to the brain when connected to the signal detector and to the signal generator;
at least one second electrode arrangement attached to the carrier substrate and spaced from the first electrode arrangement which is configured, when implanted, to face the nerve bundle including at least two separated second annular shaped electrode strips and extending axially between the at least two second electrode strips, each second electrode structure being configured when implanted to have at least two equally circumferentially spaced second electrode surfaces, and means configured, when implanted, for selectively inhibiting a selected at least one nerve fiber leading to the heart when connected to the signal generator or to another signal generator; and wherein
the means for selectively overwriting the neuronal nerve signals flowing to the brain and the means for selectively inhibiting at least one nerve fiber leading to the heart being used for treating hypertension.