US 11,850,390 B2
Systems and methods for minimally invasive drug delivery to a subarachnoid space
Adel M. Malek, Weston, MA (US); Carl B. Heilman, Wayland, MA (US); David A. Rezac, Westborough, MA (US); Jack B. Sattell, Boston, MA (US); and Alexander Bonin, Franklin, MA (US)
Assigned to Cerevasc, Inc., Auburndale, MA (US)
Filed by CEREVASC, INC., Auburndale, MA (US)
Filed on May 11, 2021, as Appl. No. 17/317,027.
Application 17/317,027 is a continuation of application No. 16/976,057, granted, now 11,013,900, previously published as PCT/US2019/021471, filed on Mar. 8, 2019.
Claims priority of provisional application 62/805,091, filed on Feb. 13, 2019.
Claims priority of provisional application 62/768,296, filed on Nov. 16, 2018.
Claims priority of provisional application 62/755,078, filed on Nov. 2, 2018.
Claims priority of provisional application 62/727,401, filed on Sep. 5, 2018.
Claims priority of provisional application 62/667,852, filed on May 7, 2018.
Claims priority of provisional application 62/640,471, filed on Mar. 8, 2018.
Prior Publication US 2021/0268252 A1, Sep. 2, 2021
Int. Cl. A61M 39/02 (2006.01); A61M 25/00 (2006.01); A61B 34/10 (2016.01); A61B 90/00 (2016.01)
CPC A61M 39/0208 (2013.01) [A61M 25/00 (2013.01); A61M 39/0247 (2013.01); A61B 2034/105 (2016.02); A61B 2034/107 (2016.02); A61B 2090/365 (2016.02); A61M 2039/0223 (2013.01); A61M 2039/0232 (2013.01); A61M 2039/0238 (2013.01); A61M 2205/32 (2013.01); A61M 2210/0687 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A for accessing an intracranial subarachnoid space (ISAS) through a blood vessel wall of a patient to administer a therapeutic agent, the method comprising:
acquiring a 3D volumetric reconstruction of the vessel wall;
identifying a target location in the 3D reconstruction for accessing the ISAS through the vessel wall with a delivery catheter;
overlaying a portion of the 3D reconstruction including the target location on a fluoroscopy imaging display of the patient's anatomy including the vessel wall;
using the overlaid portion of the 3D reconstruction and fluoroscopy imaging display to visually track movement of the delivery catheter within the vessel to the target location;
penetrating the vessel wall at the target location to create an anastomosis between the vessel and the ISAS;
accessing the ISAS through the anastomosis with the delivery catheter; and
administering a therapeutic agent from the delivery catheter into the ISAS.