US 11,850,333 B2
Coatings containing multiple drugs
James P. DeYoung, Dallas, TX (US); Charles Douglas Taylor, Franklinton, NC (US); James B. McClain, Ocracoke, NC (US); Clint Smoke, Raleigh, NC (US); and Mike Cole, Raleigh, NC (US)
Assigned to Micell Medtech Inc., Pine Plains, NY (US)
Filed by MT Acquisition Holdings LLC, Pine Plains, NY (US)
Filed on Apr. 29, 2021, as Appl. No. 17/243,769.
Application 17/243,769 is a continuation of application No. 16/223,552, filed on Dec. 18, 2018, granted, now 11,007,307.
Application 16/223,552 is a continuation of application No. 15/591,287, filed on May 10, 2017, abandoned.
Application 15/591,287 is a continuation of application No. 14/969,884, filed on Dec. 15, 2015, granted, now 9,737,645, issued on Aug. 22, 2017.
Application 14/969,884 is a continuation of application No. 14/473,741, filed on Aug. 29, 2014, granted, now 9,415,142, issued on Aug. 16, 2016.
Application 14/969,884 is a continuation of application No. 14/473,741, filed on Aug. 29, 2014, granted, now 9,415,142, issued on Aug. 16, 2016.
Application 14/473,741 is a continuation of application No. 12/298,459, granted, now 8,852,625, issued on Oct. 7, 2014, previously published as PCT/US2007/010227, filed on Apr. 26, 2007.
Claims priority of provisional application 60/912,394, filed on Apr. 17, 2007.
Claims priority of provisional application 60/745,731, filed on Apr. 26, 2006.
Claims priority of provisional application 60/745,733, filed on Apr. 26, 2006.
Prior Publication US 2021/0244861 A1, Aug. 12, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/16 (2006.01); A61L 31/10 (2006.01); A61L 31/14 (2006.01); A61F 2/90 (2013.01); A61L 31/06 (2006.01)
CPC A61L 31/16 (2013.01) [A61F 2/90 (2013.01); A61L 31/06 (2013.01); A61L 31/10 (2013.01); A61L 31/148 (2013.01); A61F 2210/0004 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/20 (2013.01); A61L 2300/216 (2013.01); A61L 2300/236 (2013.01); A61L 2300/416 (2013.01); A61L 2300/42 (2013.01); A61L 2300/426 (2013.01); A61L 2300/602 (2013.01); A61L 2300/608 (2013.01); A61L 2300/61 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01); A61L 2420/08 (2013.01)] 20 Claims
 
1. A method for depositing a coating on a substrate, comprising the steps of:
a. providing a substrate;
b. depositing at least one polymer layer onto said substrate;
c. depositing at least one pharmaceutical layer comprising a pharmaceutical agent onto said substrate without use of a solvent; and
d. sintering said at least one polymer layer so as to produce a polymer film adhered to said substrate under conditions that do not substantially modify a morphology of said pharmaceutical agent,
wherein said pharmaceutical agent comprises a morphology that is crystalline or semi-crystalline.