US 11,850,330 B2
Bioprinted hair follicles and uses thereof
Emily Bozek, San Diego, CA (US); Jonah Cool, San Diego, CA (US); Harry S. Rapoport, San Diego, CA (US); Christian Holmes, San Diego, CA (US); Stephen L. Pentoney, San Diego, CA (US); Chad Viergever, San Diego, CA (US); Howard Hwang, San Diego, CA (US); and Christopher Shaw, San Diego, CA (US)
Assigned to Organovo, Inc., San Diego, CA (US)
Appl. No. 16/349,108
Filed by Organovo, Inc., San Diego, CA (US)
PCT Filed Nov. 10, 2017, PCT No. PCT/US2017/061029
§ 371(c)(1), (2) Date May 10, 2019,
PCT Pub. No. WO2018/089750, PCT Pub. Date May 17, 2018.
Claims priority of provisional application 62/420,489, filed on Nov. 10, 2016.
Prior Publication US 2019/0275208 A1, Sep. 12, 2019
Int. Cl. A61L 27/60 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); C12N 5/071 (2010.01); A61K 35/36 (2015.01); A61K 47/36 (2006.01); A61L 27/24 (2006.01)
CPC A61L 27/60 (2013.01) [A61K 35/36 (2013.01); A61K 47/36 (2013.01); A61L 27/3813 (2013.01); A61L 27/52 (2013.01); C12N 5/0626 (2013.01); C12N 5/0627 (2013.01); C12N 5/0629 (2013.01); C12N 5/0697 (2013.01); A61L 27/24 (2013.01); C12N 2533/74 (2013.01)] 23 Claims
 
1. A composition comprising a hydrogel comprising a plurality of channels comprising removable cellular constructs that comprise cysts capable of growing hair, wherein each cellular construct is in the form of a column comprising mesenchymal cells and epithelial cells, and wherein the mesenchymal cells comprise dermal papilla cells and the epithelial cells comprise keratinocytes.