	US 11,850,278 B2
	*Compositions comprising Streptococcus pneumoniae* polysaccharide-protein conjugates and methods of use thereof**
William J. Smith, Harleysville, PA (US); Patrick McHugh, Pipersville, PA (US); Michael A. Winters, Doylestown, PA (US); Julie M. Skinner, Phoenixville, PA (US); Jian He, Blue Bell, PA (US); Luwy Musey, Blue Bell, PA (US); Chitrananda Abeygunawardana, Ambler, PA (US); Yadong Adam Cui, Norristown, PA (US); and Michael J. Kosinski, Souderton, PA (US)
Assigned to Merck Sharp & Dohme LLC, Rahway, NJ (US)
Filed by Merck Sharp & Dohme LLC, Rahway, NJ (US)
Filed on Jul. 13, 2021, as Appl. No. 17/374,424.
Application 17/374,424 is a division of application No. 16/208,778, filed on Dec. 4, 2018, granted, now 11,116,828.
Claims priority of provisional application 62/595,388, filed on Dec. 6, 2017.
Prior Publication US 2021/0379174 A1, Dec. 9, 2021
Int. Cl. A61K 39/00 (2006.01); A61K 39/09 (2006.01); A61K 39/385 (2006.01); A61K 39/145 (2006.01); A61P 31/04 (2006.01); A61K 39/116 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/22 (2006.01); A61K 9/00 (2006.01)

CPC A61K 39/092 (2013.01) [A61K 39/116 (2013.01); A61K 39/145 (2013.01); A61K 39/385 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/22 (2013.01); A61P 31/04 (2018.01); A61K 9/0019 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/70 (2013.01)]

2 Claims

1. A method for the prevention of invasive pneumococcal disease (IPD) and pneumococcal pneumonia (PP) in patients comprising administering a multivalent immunogenic composition to the patient, wherein the multivalent immunogenic composition comprises S. pneumoniae polysaccharide carrier protein conjugates, wherein each of the conjugates comprises a polysaccharide of a particular S. pneumoniae serotype conjugated to a carrier protein, wherein the S. pneumoniae serotypes consist of 3, 7F, 19A, 22F, 33F, 6A, 15A, 16F, 23A, 23B, 24F, 31, 35B, 8, 9N, 10A, 11A, 12F, de-O-acetylated 15B, 17F, and 20A, and the carrier protein is CRM197.