CPC A61K 31/352 (2013.01) [A61K 9/0056 (2013.01); A61K 45/06 (2013.01); C07D 311/30 (2013.01)] | 4 Claims |
1. A method for treating a TNF overexpression disease, comprising administering a pharmaceutically effective amount of a composition to a subject in need thereof, wherein the composition comprises
(i) a 4-benzopyranone derivative represented by Formula 1, a pharmaceutically acceptable salt, solvate, racemate, or stereoisomer thereof:
in which,
R1 is furanyl, thiophenyl, or substituted phenyl represented by
R3, R4, R5, R6, R7, R8, R9, R10, and R11 are each independently hydrogen, chloro, bromo, fluoro, or methoxyl;
R2 is hydrogen or lower alkyl of (C1-C4);
and
(ii) a drug selected from the group consisting of anti-rheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antimetabolites, anti-inflammatory agents, antibiotics, signaling/enzyme inhibitors, receptor inhibitors, HMGB1 inhibitors, antithrombotic drugs, autophagy agonists, cytokine inhibitors, HMG-CoA reductase inhibitors, antihypertensive agents, anticancer agents, immune activation agents, B cell inhibitors, and T cell inhibitors, wherein the TNF overexpression disease is selected from the group consisting of rheumatoid arthritis, juvenile rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, psoriasis, plaque psoriasis, juvenile plaque psoriasis, psoriatic arthritis, polyarticular juvenile idiopathic arthritis, Behcet's enteritis, ankylosing spondylitis, axial spondyloarthritis, juvenile enthesitis-related arthritis, osteoarthritis, polymyalgia rheumatica, multiple sclerosis, systemic lupus erythematosus, asthma, Sjogren's syndrome, pneumonia, chronic obstructive pulmonary disease, sarcoidosis, granuloma annulare, Wegener's granulomatosis, arteriosclerosis, vasculitis, heart failure, myocardial infarction, kidney injury, nephritis, graft versus host disease, dementia, Alzheimer's disease, Parkinson's disease, pain, uveitis, Behcet's disease, hidradenitis suppurativa, pityriasis rubra pilaris, necrobiosis lipoidica diabeticorum, pyoderma gangrenosum, Sweet's syndrome, subcorneal pustular dermatosis, scleroderma, neutrophilic dermatitis, dermatomyositis, sepsis, and septic shock.
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