US 11,850,040 B1
Intraoperative neural monitoring method with statistical confidence determination
Christopher Wybo, Brighton, MI (US); David S. Nay, Novi, MI (US); Darren P. Scarfe, LaSalle (CA); Lukas T. Scarfe, LaSalle (CA); and Samantha J. O'Neil, Windsor (CA)
Assigned to NEURALYTIX, LLC, Brighton, MI (US)
Filed by NEURALYTIX, LLC, Brighton, MI (US)
Filed on May 19, 2023, as Appl. No. 18/320,450.
Claims priority of provisional application 63/485,476, filed on Feb. 16, 2023.
Int. Cl. A61B 5/11 (2006.01); A61B 34/30 (2016.01); A61B 5/00 (2006.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61B 34/37 (2016.01)
CPC A61B 5/1107 (2013.01) [A61B 5/4893 (2013.01); A61B 5/726 (2013.01); A61B 5/7239 (2013.01); A61B 5/746 (2013.01); A61B 34/30 (2016.02); A61N 1/0456 (2013.01); A61N 1/36031 (2017.08); A61B 34/37 (2016.02)] 17 Claims
OG exemplary drawing
 
1. A method of alerting a user to the existence of an artificially induced neuromuscular response in a subject, the method comprising:
generating, via a processor, a series of electrical stimuli at a predetermined period and transmitting the series of electrical stimuli to an electrode disposed at a distal end portion of an elongate medical device;
receiving, by the processor, an indication of a physical movement of the muscle from a mechanical sensor in mechanical communication with a muscle of the subject;
detecting, by the processor, a series of mechanomyographic (MMG) responses of the muscle from the received indication of the physical movement, each MMG response indicative of a contraction of a muscle of the subject;
determining, via the processor in communication with both the electrode and the mechanical sensor, a degree of statistical confidence that the detected series of MMG responses was artificially induced by the series of electrical stimuli, wherein the degree of statistical confidence is a function of a periodicity of the series of MMG responses and the predetermined period of the electrical stimuli;
outputting, to the user, via a display in communication with the processor, both:
an alert that a series of MMG responses has been detected; and
an indication of the determined degree of statistical confidence that the detected series of MMG responses was artificially induced by the series of electrical stimuli.