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18. A method of making a flexible tubing for a cannula of an infusion device having a base configured to secure to a patient's skin, the method comprising: forming by molding a hollow tubing body having a length dimension extending from a first end to a second end and no more than one fluid outlet opening, the fluid outlet opening located at the second end of the tubing body, the tubing body having a tubing wall with an inner surface and an outer surface; extending the tubular body from the base; providing the tubing body with at least one section of enhanced flexibility located between the first and the second end, the at least one section of enhanced flexibility having a greater flexibility than one or more other sections of the tubing body; and providing a plurality of bumps, bubbles or protrusions on the inner surface of the tubing wall separate from each section of enhanced flexibility, and protruding inward from the inner surface; wherein providing the tubing body with at least one section of enhanced flexibility comprises providing one or more folds or convolutions in a wall of the tubing, wherein the folds or convolutions define an accordion-like structure in the tubing wall configured to at least partially unfold on one side of the tubing body when the tubing body is bent at the section of enhanced flexibility, wherein the tubing wall is uniform in material between the inner and the outer surface, and wherein the at least one section of enhanced flexibility comprising the one or more folds or convolutions is provided on the inner surface of the tubing wall, but not on the outer surface of the tubing wall.
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