US 11,842,556 B2
Image analysis method, apparatus, program, and learned deep learning algorithm
Yosuke Sekiguchi, Kobe (JP); Kazumi Hakamada, Kobe (JP); Yuki Aihara, Kobe (JP); Kohei Yamada, Kobe (JP); Kanako Masumoto, Kobe (JP); and Krupali Jain, Kobe (JP)
Assigned to SYSMEX CORPORATION, Kobe (JP)
Filed by SYSMEX CORPORATION, Kobe (JP)
Filed on Jun. 21, 2021, as Appl. No. 17/352,488.
Application 17/352,488 is a continuation of application No. 16/193,422, filed on Nov. 16, 2018, granted, now 11,074,692.
Claims priority of application No. 2017-222178 (JP), filed on Nov. 17, 2017.
Prior Publication US 2021/0312627 A1, Oct. 7, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G06V 20/69 (2022.01); G06V 10/44 (2022.01); G06V 10/56 (2022.01); G06T 7/73 (2017.01); G06T 7/90 (2017.01); G06T 7/00 (2017.01)
CPC G06V 20/698 (2022.01) [G06T 7/0014 (2013.01); G06T 7/74 (2017.01); G06T 7/90 (2017.01); G06V 10/44 (2022.01); G06V 10/56 (2022.01); G06T 2207/20084 (2013.01); G06T 2207/30024 (2013.01)] 14 Claims
OG exemplary drawing
 
1. An image analysis method for analyzing an image of a tissue or a cell to be analyzed using a deep learning algorithm of a neural network structure, the method comprising:
generating analysis data from an analysis target image that include the tissue or the cell to be analyzed;
inputting the analysis data to the deep learning algorithm, and
generating data indicating a region of a cell nucleus in the analysis target image by the deep learning algorithm,
wherein training data used for learning of the deep learning algorithm are generated based on a bright field image of a tissue specimen or a sample containing a cell captured under a bright field microscope and a fluorescence image of a cell nucleus in the same tissue specimen or the same sample prepared by applying fluorescent nuclear stain to the same tissue specimen or the same sample for fluorescence observation by a fluorescence microscope, wherein the fluorescence image is converted to binary data indicating which part of the fluorescence image is the cell nucleus region, and
the analysis target image is a bright field image.