US 11,840,705 B2
Biomimetic double network hydrogels
Paul Kouwer, Nijmegen (NL); Alan Rowan, Nijmegen (NL); Maarten Jaspers, Nijmegen (NL); and Paula De Almeida, Nijmegen (NL)
Assigned to STICHTING RADBOUD UNIVERSITEIT, Nijmegen (NL)
Appl. No. 16/607,824
Filed by STICHTING KATHOLIEKE UNIVERSITEIT, Nijmegen (NL)
PCT Filed Apr. 23, 2018, PCT No. PCT/EP2018/060348
§ 371(c)(1), (2) Date Oct. 24, 2019,
PCT Pub. No. WO2018/197416, PCT Pub. Date Nov. 1, 2018.
Claims priority of application No. 17167774 (EP), filed on Apr. 24, 2017.
Prior Publication US 2020/0181564 A1, Jun. 11, 2020
Int. Cl. C12N 5/18 (2006.01); C12N 5/00 (2006.01); C09D 133/26 (2006.01); C08J 3/24 (2006.01); C08F 120/54 (2006.01)
CPC C12N 5/0018 (2013.01) [C08F 120/54 (2013.01); C08J 3/246 (2013.01); C09D 133/26 (2013.01); C08J 2333/02 (2013.01); C08J 2333/26 (2013.01); C08J 2477/04 (2013.01); C12N 2533/40 (2013.01); C12N 2533/54 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A double network hydrogel comprising:
a. a polymer (A) having a persistence length between 10 and 1000 nm,
b. a polymer (B) having a persistence length smaller than 1 nm,
wherein the persistence length is measured at room temperature in an aqueous solution at neutral pH according to single molecule force microscopy measurement,
wherein polymer (B) has an extended coil conformation at a first condition and a collapsed globular conformation at a second condition,
wherein the concentration of polymer (B) ranges between 1 and 80 mg/mL,
wherein the polymer (B) is a temperature responsive (thermoresponsive) polymer having a lower critical solution temperature (LCSTb), whereby the first condition is present at a temperature below LCSTb and the second condition is present at a temperature above the LCSTb,
wherein the polymer (A) has a lower critical solution temperature (LCSTa),
wherein the LCSTb is higher than the LCSTa, and
wherein the LCSTa is between 5° C. and 20° C.