US 11,840,551 B2
Compositions and methods of modulating the immune response by activating alpha protein kinase 1
Tian Xu, Shanghai (CN); Cong Xu, Shanghai (CN); Danyang Liu, Shanghai (CN); Jieqing Fan, Shanghai (CN); Yanfang Pan, Shanghai (CN); Tongruei Raymond Li, Shanghai (CN); and Xiaodong Chen, Shanghai (CN)
Assigned to Shanghai Yao Yuan Biotechnology Co., Ltd., Shanghai (CN)
Filed by Shanghai Yao Yuan Biotechnology Co., Ltd., Shanghai (CN)
Filed on Aug. 16, 2021, as Appl. No. 17/445,122.
Application 17/445,122 is a division of application No. 16/395,463, filed on Apr. 26, 2019, granted, now 11,149,051.
Application 16/395,463 is a continuation in part of application No. PCT/CN2018/111885, filed on Oct. 25, 2018.
Application PCT/CN2018/111885 is a continuation of application No. PCT/CN2018/100871, filed on Aug. 16, 2018.
Application PCT/CN2018/100871 is a continuation of application No. PCT/CN2018/083153, filed on Apr. 16, 2018.
Application PCT/CN2018/083153 is a continuation of application No. PCT/CN2017/107962, filed on Oct. 27, 2017.
Prior Publication US 2022/0017560 A1, Jan. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61P 11/06 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01); A61K 31/7076 (2006.01); A61K 39/00 (2006.01); C07H 19/20 (2006.01)
CPC C07H 19/20 (2013.01) [A61K 31/7076 (2013.01); A61P 11/00 (2018.01); A61P 11/06 (2018.01); A61P 35/00 (2018.01); A61K 39/00 (2013.01)] 14 Claims
 
1. A method for treating a disease or disorder amenable to treatment by activation of NFkB, p38, and JNK cell signaling pathways in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound selected from:

OG Complex Work Unit Chemistry
or a stereoisomer, stable isotope, prodrug or a pharmaceutically acceptable salt thereof, wherein the disease or disorder is selected from tuberculosis, meningitis, pneumonia, ulcer, sepsis, rhinitis, asthma, allergy, chronic obstructive pulmonary disease (COPD), cancer, inflammatory bowel disease, arthritis, obesity, radiation-induced inflammation, psoriasis, atopic dermatitis, non-alcoholic steatohepatitis (NASH), Alzheimer's disease, systemic lupus, erythematosus (SLE), autoimmune thyroiditis (Grave's disease), multiple sclerosis, ankylosing spondylitis bullous diseases, actinic keratoses, ulcerative colitis, Crohn's disease, alopecia areata, and diseases and disorders caused by the hepatitis C virus (HCV), the hepatitis B virus (HBV), or the human immunodeficiency virus (HIV).