| CPC C07D 471/04 (2013.01) [A61K 31/4375 (2013.01); A61P 35/00 (2018.01)] | 15 Claims |
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1. A compound of formula I:
 or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein L is —[CH2]0-3—, —[CH2]0-2—C(O)—, —C(O)—[CH2]0-2—;
R is —NR4R5, —OR6;
R1 is —NR2R3;
R2 and R3 is independently H; C1-6 alkyl, unsubstituted or substituted by one or several substituents R7; C2-6 alkenyl, unsubstituted or substituted by one or several substituents R7; C2-6 alkynyl, unsubstituted or substituted by one or several substituents R7; C3-7 cycloalkyl, unsubstituted or substituted by one or several substituents R8; C3-7 cycloalkenyl, unsubstituted or substituted by one or several substituents R8; 5-6 membered heterocyclyl with 1-2 heteroatoms, selected from N, O and/or S, unsubstituted or substituted by one or several substituents R9; aryl, unsubstituted or substituted by one or several substituents R10; heteroaryl with 1-4 heteroatoms, selected from N, O and/or S, unsubstituted or substituted by one or several substituents R11, or
R2 and R3 together with the nitrogen atom they are attached to, form 4-7-membered heterocyclic ring with 1-3 heteroatoms, selected from N and/or O, wherein heterocyclic ring, formed by R2 and R3, could be unsubstituted or substituted by one or several substituents R9;
R4 and R5 is independently H; C1-6 alkyl, unsubstituted or substituted by one or several substituents R12; C2-6 alkenyl, unsubstituted or substituted by one or several substituents R12; C2-6 alkynyl, unsubstituted or substituted by one or several substituents R12; C3-7 cycloalkyl, unsubstituted or substituted by one or several substituents R13; C3-7 cycloalkenyl, unsubstituted or substituted by one or several substituents R13; 5-6 membered heterocyclyl with 1-2 heteroatoms, selected from N, O and/or S, unsubstituted or substituted by one or several substituents R14; aryl, unsubstituted or substituted by one or several substituents R15; heteroaryl with 1-4 heteroatoms, selected from N, O and/or S, unsubstituted or substituted by one or several substituents R16, or
R4 and R5 together with the nitrogen atom they are attached to, form 4-7-membered heterocyclic ring with 1-3 heteroatoms, selected from N and/or O, wherein heterocyclic ring, formed by R4 and R5, could be unsubstituted or substituted by one or several substituents R14;
R6 is H; C1-6 alkyl, unsubstituted or substituted by one or several substituents R17;
each R7 and R12 is independently H, Hal, CN, —OR18, —NR19R20, —C(═O)R18, —C(═O)NR19R20, —NR21C(═O)R18; —NR21C(═O) NR19R20; C3-7 cycloalkyl, unsubstituted or substituted by one or several radicals, selected from C1-6 alkyl, halogen;
each R9 and R14 is independently H, Hal, CN, —OR18, —NR19R20, —C(═O)R18, —C(═O)NR19R20, —NR21C(═O)R18; —NR21C(═O) NR19R20; oxo group, C1-6 alkyl, unsubstituted or substituted by one or several halogens; C3-7 cycloalkyl, unsubstituted or substituted by one or several radicals, selected from C1-6 alkyl, halogen;
each R8, R10, R11, R13, R15 and R16 is independently H, Hal, CN, —OR18, —NR19R20, —C(═O)R18, —C(═O)NR19R20, —NR21C(═O)R18; —NR21LC(═O)NR19R20; C1-C6 alkyl, unsubstituted or substituted by one or several halogens; C3-7 cycloalkyl, unsubstituted or substituted by one or several radicals, selected from C1-6 alkyl, halogen;
each R17, R18, R19, R20 and R21 is independently H, C1-C6 alkyl, unsubstituted or substituted by one or several halogens; C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, unsubstituted or substituted by one or several radicals, selected from C1-6 alkyl, halogen; or
R19 and R20 together with the nitrogen atom they are attached to, form 4-7-membered heterocyclic ring with 1-3 heteroatoms, selected from N and/or O, wherein the heterocyclic ring, formed by R19 and R20, could be unsubstituted or substituted by 1 or 2 substituents, selected from oxo group; Hal; OH; NH2; CN; C1-6 alkyl, unsubstituted or substituted by one or several halogens; C1-6 alkoxy; C1-6 alkylamino.
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