US 11,840,517 B2
Lappaconitine derivative with analgesic activity, and preparation and application thereof
Xianli Zhou, Chengdu (CN); Feng Gao, Chengdu (CN); Xiaohuan Li, Chengdu (CN); Yuzhu Li, Chengdu (CN); Shuai Huang, Chengdu (CN); Lin Chen, Chengdu (CN); and Yinyong Zhang, Chengdu (CN)
Assigned to Southwest Jiaotong University, Chengdu (CN)
Filed by Southwest Jiaotong University, Chengdu (CN)
Filed on Jan. 22, 2022, as Appl. No. 17/581,920.
Claims priority of application No. 202110419203.4 (CN), filed on Apr. 19, 2021.
Prior Publication US 2022/0144779 A1, May 12, 2022
Int. Cl. C07D 221/22 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); A61P 29/00 (2006.01); A61K 31/439 (2006.01); A61K 31/4709 (2006.01); C07D 223/32 (2006.01)
CPC C07D 223/32 (2013.01) 10 Claims
 
1. A compound of formula (III), or a stereoisomer, a deuterated compound or a pharmaceutically acceptable salt thereof

OG Complex Work Unit Chemistry
wherein M is O or NH;
R1 is C1-4 alkyl, C1-4 alkoxy, C2-4 alkenyl, C2-4 alkynyl, 5-6 membered aryl or 5-6 membered heteroaryl.