US 11,839,835 B2
Simulated moving-bed type chromatographic separation method and simulated moving-bed type chromatographic separation system
Kazuo Okada, Tokyo (JP); Masahiro Ogino, Tokyo (JP); Kohei Sato, Tokyo (JP); Masaki Tsuruta, Tokyo (JP); and Toshiki Miyajima, Tokyo (JP)
Assigned to ORGANO CORPORATION, Tokyo (JP)
Appl. No. 17/277,077
Filed by ORGANO CORPORATION, Tokyo (JP)
PCT Filed Oct. 8, 2019, PCT No. PCT/JP2019/039702
§ 371(c)(1), (2) Date Mar. 17, 2021,
PCT Pub. No. WO2020/100471, PCT Pub. Date May 22, 2020.
Claims priority of application No. 2018-215950 (JP), filed on Nov. 16, 2018; and application No. 2019-088523 (JP), filed on May 8, 2019.
Prior Publication US 2022/0032208 A1, Feb. 3, 2022
Int. Cl. B01D 15/18 (2006.01); G01N 30/44 (2006.01)
CPC B01D 15/185 (2013.01) [B01D 15/1828 (2013.01); G01N 30/44 (2013.01); B01D 2215/024 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A simulated moving-bed type chromatographic separation method comprising separating a weakly adsorptive component, a strongly adsorptive component, and an intermediately adsorptive component that has intermediate adsorptive property in relation to both components, with respect to an adsorbent, with two or more kinds of eluents by using a circulation system in which a plurality of unit packed columns packed with the adsorbent are connected in series and in an endless form via pipes, the weakly adsorptive component, the strongly adsorptive component, and the intermediately adsorptive component being contained in a feed solution, wherein a feed solution supply port F, two or more eluent supply ports D corresponding to the two or more kinds of eluents, an extraction port A of a weakly adsorptive fraction containing the weakly adsorptive component, an extraction port B of an intermediately adsorptive fraction containing the intermediately adsorptive component, and an extraction port C of a strongly adsorptive fraction containing the strongly adsorptive component are provided in the pipes of the circulation system, and positions of the feed solution supply port F, the extraction port A, the extraction port B, and the extraction port C are set as described in the following (a) to (c):
(a) the extraction port B is provided on the downstream side of the feed solution supply port F with at least one unit packed column interposed therebetween;
(b) the extraction port C is provided in the pipe having the feed solution supply port F or the extraction port C is provided on the upstream side of the feed solution supply port F with at least one unit packed column interposed therebetween; and
(c) the extraction port A is provided in the pipe having the extraction port B or the extraction port A is provided on the downstream side of the extraction port B with at least one unit packed column interposed therebetween, and
wherein the chromatographic separation method comprises sequentially repeating (A) and (B):
[(A)]
simultaneously or separately supplying the feed solution and the two or more kinds of eluents from the feed solution supply port F and the two or more eluent supply ports D respectively, and simultaneously or separately extracting the weakly adsorptive fraction, the intermediately adsorptive fraction, and the strongly adsorptive fraction from the extraction port A, the extraction port B, and the extraction port C respectively; and
[(B)]
shifting the feed solution supply port F, the eluent supply ports D, the extraction port A, the extraction port B, and the extraction port C to the downstream side, while maintaining a relative positional relationship therebetween, after finishing (A).