US 11,839,699 B2
3D printed scaffolds of peptide conjugate polymer
Lesley W. Chow, Bethlehem, PA (US); Hannah L. Dailey, Neshanic Station, NJ (US); Hafiz Busari, Greenville, SC (US); Peter Schwarzenberg, Fountain Hill, PA (US); and Katherine Hudson, Hopkinton, MA (US)
Assigned to Lehigh University
Appl. No. 16/632,992
Filed by Lehigh University, Bethlehem, PA (US)
PCT Filed Jul. 23, 2018, PCT No. PCT/US2018/043262
§ 371(c)(1), (2) Date Jan. 22, 2020,
PCT Pub. No. WO2019/023119, PCT Pub. Date Jan. 31, 2019.
Claims priority of provisional application 62/535,955, filed on Jul. 23, 2017.
Prior Publication US 2020/0206384 A1, Jul. 2, 2020
Int. Cl. B33Y 80/00 (2015.01); A61L 27/54 (2006.01); B33Y 10/00 (2015.01); B33Y 70/00 (2020.01); B29C 64/106 (2017.01); A61L 27/18 (2006.01); A61L 27/58 (2006.01); B29K 67/00 (2006.01); B29L 31/00 (2006.01)
CPC A61L 27/54 (2013.01) [A61L 27/18 (2013.01); A61L 27/58 (2013.01); B29C 64/106 (2017.08); B33Y 10/00 (2014.12); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); A61L 2430/02 (2013.01); A61L 2430/06 (2013.01); A61L 2430/10 (2013.01); A61L 2430/24 (2013.01); B29K 2067/00 (2013.01); B29K 2089/00 (2013.01); B29L 2031/7532 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure:
X-Y-Z-Y-X
wherein X is a biologically active peptide; Y is a linker moiety comprising a maleimide functionalized compound and at least one of a hydroxyl-reactive group, an aromatic group, or an aliphatic chain; and Z is a biocompatible polymer.