	US 11,839,629 B2
	Methods and compositions to modulate hair growth
Alexey V. Terskikh, Solana Beach, CA (US)
Assigned to SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US)
Filed by Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US)
Filed on May 22, 2020, as Appl. No. 16/882,142.
Application 16/882,142 is a division of application No. 15/320,529, granted, now 10,716,808, previously published as PCT/US2015/039397, filed on Jul. 7, 2015.
Claims priority of provisional application 62/022,639, filed on Jul. 9, 2014.
Prior Publication US 2020/0345772 A1, Nov. 5, 2020
Int. Cl. A61K 35/12 (2015.01); C12N 5/071 (2010.01); C12N 5/0775 (2010.01); G01N 33/50 (2006.01)

CPC A61K 35/12 (2013.01) [C12N 5/0627 (2013.01); C12N 5/0662 (2013.01); G01N 33/5044 (2013.01); C12N 2500/38 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2506/02 (2013.01); C12N 2506/13 (2013.01); C12N 2533/30 (2013.01); C12N 2533/52 (2013.01)]

19 Claims

1. A method for inducing hair growth in a subject comprising administering a population of stem cell-derived dermal papillae-like cells to the subject, wherein the population of stem cell-derived dermal papillae-like cells were obtained via:

culturing adherent cells from a population of stem cell-derived neural crest cells, wherein the population of stem cell-derived neural crest cells lack a marker selected from the group consisting of versican, smooth muscle actin, and alkaline phosphatase, and

differentiating the adherent cells into the population of stem-cell derived dermal papillae-like cells in a serum-containing media,

thereby inducing hair growth in the subject.