US 11,839,483 B2
Evaluation of dermal filler injections by optical coherence tomography and optical coherence elastography
Kirill Larin, Friendswood, TX (US); Richard Yee, Houston, TX (US); and Manmohan Singh, Houston, TX (US)
Assigned to UNIVERSITY OF HOUSTON SYSTEM, Houston, TX (US)
Appl. No. 15/748,372
Filed by University of Houston System, Houston, TX (US)
PCT Filed Aug. 25, 2016, PCT No. PCT/US2016/048636
§ 371(c)(1), (2) Date Jan. 29, 2018,
PCT Pub. No. WO2017/035328, PCT Pub. Date Mar. 2, 2017.
Claims priority of provisional application 62/210,195, filed on Aug. 26, 2015.
Prior Publication US 2018/0214069 A1, Aug. 2, 2018
Int. Cl. A61B 5/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/442 (2013.01) [A61B 5/0066 (2013.01); A61B 5/4839 (2013.01); A61B 5/4848 (2013.01); A61B 2090/3735 (2016.02); A61B 2505/05 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for quantifying effects of a treatment on elasticity of skin in an area of skin, comprising the steps of:
performing a treatment on an area of skin, wherein the treatment produces a zone of skin manipulation within the area of skin, and wherein the treatment comprises an injection of a dermal filler, cross-linking of an injected dermal filler, application of a cream or lotion, or resurfacing;
using a single focused air pulse to stimulate a localized micrometer scale displacement of the skin at a single location within the zone of skin manipulation;
using an optical coherence elastography (OCE) system to measure a temporal displacement profile resulting from the localized micrometer scale displacement of the skin at the single location within the zone of skin manipulation, wherein the temporal displacement profile shows amount of displacement of the skin measured relative to time at the single location;
quantifying biomechanical properties at the single location within the zone of skin manipulation based on an analysis of the temporal displacement profile; and
mapping one or more biomechanical properties to the single location within the zone of skin manipulation to quantify the effects of the treatment on the elasticity of the skin in the area of skin.