US 12,493,048 B2
Antibodies binding specifically to NT-proBNP and use thereof
Jung Ho Kim, Hwaseong-si (KR); Se Jung Lee, Hwaseong-si (KR); Sun Nyeo Jeong, Hwaseong-si (KR); Soung Jin Ji, Hwaseong-si (KR); Ji Su Lee, Hwaseong-si (KR); Hye Rim Kim, Hwaseong-si (KR); Eun Young Sa, Hwaseong-si (KR); Bo Ram Lee, Hwaseong-si (KR); Jin Soo Kim, Hwaseong-si (KR); and Hwa Young Im, Hwaseong-si (KR)
Assigned to BIONOTE, INC., Hwaseong-si (KR)
Filed by BIONOTE, INC., Hwaseong-si (KR)
Filed on Sep. 28, 2022, as Appl. No. 17/955,111.
Claims priority of application No. 10-2021-0143038 (KR), filed on Oct. 25, 2021; and application No. 10-2022-0031497 (KR), filed on Mar. 14, 2022.
Prior Publication US 2023/0288436 A1, Sep. 14, 2023
Int. Cl. C07K 16/26 (2006.01); G01N 33/74 (2006.01)
CPC G01N 33/74 (2013.01) [C07K 16/26 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); G01N 2333/58 (2013.01); G01N 2800/325 (2013.01)] 8 Claims
 
1. An antibody or antigen-binding fragment thereof, which specifically binds to an epitope of N-terminal pro-B-type natriuretic peptide (NT-proBNP) comprising the amino acid sequence of HXLGXXX,
wherein the antibody or antigen-binding fragment thereof comprises:
a heavy chain variable region comprising heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO: 4, heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO: 5, and heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO: 6; and
a light chain variable region comprising light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO: 7, light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO: 8, and light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO: 9.