US 12,491,271 B2
Positron emission tomography radiotracer for diseases associated with translocator protein overexpression, translocator protein-targeting ligand for fluorescence imaging-guided surgery and photodynamic therapy, and production methods therefor
Sang Eun KIM, Seoul (KR); Byung Chul Lee, Hanam-si (KR); Sang Hee Lee, Seongnam-si (KR); Nunzio Denora, Conversano (IT); Valentino Laquintana, Monopoli (IT); Angela Assunta Lopedota, Matera (IT); Annalisa Cutrignelli, Bari (IT); and Massimo Franco, Bari (IT)
Assigned to SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
Filed by Seoul National University R&DB Foundation, Seoul (KR)
Filed on Jan. 23, 2024, as Appl. No. 18/419,562.
Application 18/419,562 is a continuation of application No. 16/929,803, filed on Jul. 15, 2020, abandoned.
Application 16/929,803 is a continuation of application No. PCT/KR2018/015117, filed on Nov. 30, 2018.
Claims priority of application No. 10-2018-0007226 (KR), filed on Jan. 19, 2018.
Prior Publication US 2024/0156997 A1, May 16, 2024
Int. Cl. A61K 51/04 (2006.01); C07B 59/00 (2006.01)
CPC A61K 51/0455 (2013.01) [C07B 59/002 (2013.01)] 2 Claims
 
1. A method for diagnosing neuroinflammation, stroke or cerebral infarction in a subject, comprising administering the fluorine-18-labeled PET radiotracer represented by Formula below to a subject,
obtaining in vivo brain PET images of the uptake of the fluorine-18-labeled positron emission tomography (PET) radiotracer in the subject,
evaluating the uptake of the fluorine-18-labeled radiotracer in brain

OG Complex Work Unit Chemistry