US 12,491,061 B2
Biomedical patches with aligned fibers
Matthew R. MacEwan, St. Louis, MO (US); Jingwei Xie, Chesapeake, OH (US); Zack Ray, St. Louis, MO (US); and Younan Xia, Atlanta, GA (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on Jul. 23, 2021, as Appl. No. 17/383,958.
Application 16/130,005 is a division of application No. 13/703,210, granted, now 10,149,749, issued on Dec. 11, 2018, previously published as PCT/US2011/040691, filed on Jun. 16, 2011.
Application 17/383,958 is a continuation of application No. 17/229,171, filed on Apr. 13, 2021, granted, now 11,096,772.
Application 17/229,171 is a continuation of application No. 16/130,005, filed on Sep. 13, 2018, granted, now 11,000,358, issued on May 11, 2021.
Claims priority of provisional application 61/355,712, filed on Jun. 17, 2010.
Prior Publication US 2022/0175510 A1, Jun. 9, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/02 (2006.01); A61F 2/00 (2006.01); A61F 2/10 (2006.01); A61L 15/22 (2006.01); A61L 15/42 (2006.01); A61L 27/14 (2006.01); A61L 27/50 (2006.01); B29C 48/05 (2019.01); B29C 48/14 (2019.01); D01D 5/00 (2006.01); D04H 1/728 (2012.01); D04H 3/016 (2012.01); D04H 3/073 (2012.01); C12M 1/12 (2006.01)
CPC A61F 2/02 (2013.01) [A61F 2/0063 (2013.01); A61F 2/105 (2013.01); A61L 15/22 (2013.01); A61L 15/42 (2013.01); A61L 27/14 (2013.01); A61L 27/50 (2013.01); B29C 48/05 (2019.02); B29C 48/142 (2019.02); D01D 5/0076 (2013.01); D01D 5/0092 (2013.01); D04H 1/728 (2013.01); D04H 3/016 (2013.01); D04H 3/073 (2013.01); C12M 25/14 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A fiber structure for repairing a void in a biological tissue, the fiber structure comprising a set of one or more inner point(s), a set of one or more inner area(s) extending from the one or more inner point(s) to a set of one or more inner perimeter(s), and a set of one or more outer area(s) extending from the one or more inner perimeter(s) to a set of one or more outer perimeter(s), wherein the one or more inner area(s) and the one or more outer area(s) at least partially overlap, the fiber structure comprising a first set of one or more substantially straight polymeric fiber sections extending from the inner point(s) to the inner perimeter(s), and a second set of one or more substantially straight polymeric fiber sections extending from the inner perimeter(s) to the outer perimeter(s),
wherein a spatial fiber density of the one or more inner area(s) is substantially the same as a spatial fiber density of the one or more outer area(s),
wherein each of the first set of one or more of substantially straight polymeric fiber sections and the second set of one or more of substantially straight polymeric fiber sections comprise one or more fiber sections generated by depositing via electrospinning a first polymer composition and one or more fiber sections generated by depositing via electrospinning a second polymer composition, and
wherein the first set of one or more substantially straight polymeric fiber sections transitions into a randomly oriented fiber section.