| CPC A61B 5/14532 (2013.01) [A61B 5/1468 (2013.01); A61B 2560/0247 (2013.01); A61B 2562/12 (2013.01)] | 20 Claims |

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1. A method for initializing a glucose sensor, the method comprising:
determining a current profile for current flowing through a working electrode of the glucose sensor based on one or more parameters related to manufacturing of the glucose sensor or environmental conditions of the glucose sensor that are present in vivo, wherein the current profile comprises a slope of the current over time;
determining one or more parameters of a sequence of voltage pulses of an initialization sequence based on the current profile, wherein the one or more parameters comprise a voltage amplitude of the sequence of voltage pulses based at least in part on the slope of the current;
executing the initialization sequence by applying the sequence of voltage pulses to the working electrode of the glucose sensor at least partially inserted subcutaneously in a patient; and
reporting glucose levels in a patient after the initialization sequence.
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