US 11,835,536 B2
Device and method for qualitative and quantitative analysis of heavy metals utilizing rotary disc system
Byung Hyun Park, Daejeon (KR); Byoung Hyoun Kim, Daejeon (KR); Dong Hyun Kim, Daejeon (KR); and Su Youn Han, Daejeon (KR)
Assigned to LG Chem, Ltd.
Appl. No. 16/638,350
Filed by LG Chem, Ltd., Seoul (KR)
PCT Filed Oct. 25, 2018, PCT No. PCT/KR2018/012738
§ 371(c)(1), (2) Date Feb. 11, 2020,
PCT Pub. No. WO2019/098536, PCT Pub. Date May 23, 2019.
Claims priority of application No. 10-2017-0154395 (KR), filed on Nov. 20, 2017; and application No. 10-2018-0053639 (KR), filed on May 10, 2018.
Prior Publication US 2020/0254449 A1, Aug. 13, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/78 (2006.01); G01N 31/22 (2006.01); G01N 21/75 (2006.01); G01N 21/77 (2006.01); G01N 35/10 (2006.01); G01N 35/08 (2006.01); B01L 3/00 (2006.01); G01N 33/20 (2019.01)
CPC G01N 35/1095 (2013.01) [B01L 3/5027 (2013.01); B01L 3/50273 (2013.01); B01L 3/502715 (2013.01); G01N 21/78 (2013.01); G01N 31/22 (2013.01); G01N 33/20 (2013.01); G01N 35/08 (2013.01); B01L 2200/16 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0803 (2013.01); B01L 2300/126 (2013.01); B01L 2300/16 (2013.01); B01L 2400/0475 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A device for qualitative analysis and quantitative analysis comprising a rotatable platform and a plurality of microfluidic structures disposed radially and symmetrically on the rotatable platform, wherein each of the plurality of the microfluidic structures comprises:
a sample injection unit configured to receive an injection of a respective fluid sample containing heavy metals, an entirety of the sample injection unit being located in a top layer of the rotatable platform, the sample injection unit including a space configured to receive an entirety of the respective fluid sample stored therein and an opening configured to receive the injection of the respective fluid sample;
a microfluidic siphon channel which is a passage providing fluid communication between the sample injection unit and one end of a detection unit;
the detection unit comprising a plurality of detection members each being coated with a respective different reagent, each reagent containing a different organic material, each organic material containing organic ligands configured to produce a color development reaction with the heavy metals of the fluid sample; and
a ruler configured to measure a color developed distance of the color development reaction, the ruler being positioned alongside the detection unit,
wherein each of the plurality of the microfluidic structures is configured to receive a different kind of the respective fluid samples than other ones of the plurality of the microfluidic structures,
wherein the device is configured to move the respective fluid samples from the respective sample injection unit to the respective microfluidic channel and then to the respective detection unit when the rotatable platform is rotated,
wherein the device is configured to provide the qualitative analysis of the fluid samples through the respective color development reaction of the heavy metals in the respective detection unit and the device is configured to provide the quantitative analysis of the fluid samples through measurement of the respective color developed distances,
wherein each detection unit comprises a respective reservoir area which connects one end of each of the plurality of the detection members with the respective microfluidic channel, each of the detection members of each detection unit comprises a respective plurality of three or more sections coated with the respective different reagent, each section being coated with the respective organic material having different respective concentrations of the organic ligands, an entirety of each section being coated with the respective organic material having the different respective concentrations of the organic ligands, each of the detection members comprising a respective development area coated with the respective organic material configured to produce the color development reaction with the heavy metals of the respective fluid sample so that the respective fluid sample is developed,
wherein the development area of each detection member is located closer to a center of the rotatable platform than the reservoir area of the respective detection unit, such that each detection member is configured to move the respective fluid sample from the respective reservoir to the respective development area in a direction from a periphery of the rotatable platform towards the center of the rotatable platform via a capillary force, and
the plurality of sections of each detection member being disposed adjacent to one another along a longitudinal direction of the detection member, the plurality of sections of each detection member being configured to receive a respective portion of a respective one of the fluid samples flowing successively through the sections from a first section closest to the respective reservoir area towards a last section farthest from the respective reservoir area, the first section of each development area being coated with a highest concentration of the organic ligand, the plurality of sections of each detection member being continuously arranged so that boundaries thereof are in contact with each other along the longitudinal direction of the detection member.