US 11,834,428 B2
Dihydromyricetin nanocrystals and preparation method and application thereof
Yang Kong, Xi'an (CN); ChangZhao Wang, Xi'an (CN); Bin Tian, Xi'an (CN); Fang Lin, Xi'an (CN); and Zihao Li, Xi'an (CN)
Assigned to SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY, Xi'an (CN)
Filed by Shaanxi University of Science and Technology, Xi'an (CN)
Filed on Mar. 1, 2023, as Appl. No. 18/116,204.
Claims priority of application No. 202210227200.5 (CN), filed on Mar. 8, 2022.
Prior Publication US 2023/0286935 A1, Sep. 14, 2023
Int. Cl. C07D 311/30 (2006.01)
CPC C07D 311/30 (2013.01) [C07B 2200/13 (2013.01)] 2 Claims
 
1. A method for preparing dihydromyricetin nanocrystals solid preparation, comprising:
uniformly dispersing dihydromyricetin in a good solvent to obtain a dihydromyricetin solution;
uniformly dispersing a precipitator and a stabilizer in water to obtain a mixed solution, and adding the dihydromyricetin solution into the mixed solution and then mixing uniformly under a stirring condition to obtain a target solution; and
drying the target solution to obtain the dihydromyricetin solid preparation comprising the stabilizer and dihydromyricetin nanocrystals;
wherein particle sizes of the dihydromyricetin nanocrystals are less than or equal to 300 nanometers (nm);
wherein the good solvent is at least one selected from a group consisting of ethanol, ethyl acetate, n-butanol and acetone; and a dosage ratio of the dihydromyricetin to the good solvent is 50 milligrams (mg): 1 milliliter (mL);
wherein the stabilizer is one of sodium dodecyl sulfate and Tween-80, and a volume ratio of the precipitator to the one of the sodium dodecyl sulfate and the Tween-80 is 1˜4 mL: 0.1 mg;
wherein the precipitator is at least one selected from a group consisting of water, chloroform and petroleum ether.