US 11,833,519 B2
Co-axial plunger based home molecular diagnostics kit
Manu Prakash, San Francisco, CA (US); Anesta Kothari, San Francisco, CA (US); Adam George Larson, San Francisco, CA (US); Shailabh Kumar, Sunnyvale, CA (US); and Hazel Soto-Montoya, Mountain View, CA (US)
Assigned to The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Filed by The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Filed on Apr. 26, 2021, as Appl. No. 17/240,767.
Claims priority of provisional application 63/120,401, filed on Dec. 2, 2020.
Claims priority of provisional application 63/085,664, filed on Sep. 30, 2020.
Prior Publication US 2022/0097073 A1, Mar. 31, 2022
Int. Cl. B01L 3/00 (2006.01); B01L 7/00 (2006.01); B01L 3/02 (2006.01)
CPC B01L 7/52 (2013.01) [B01L 3/0217 (2013.01); B01L 3/5023 (2013.01)] 9 Claims
OG exemplary drawing
 
1. Apparatus for performing biological tests, the apparatus comprising:
a hollow plunger including an axis, a side wall, an aperture in the side wall, a first seal and a second seal such that the first and second seals and the side wall of the plunger enclose a reaction chamber, wherein the reaction chamber includes a capture matrix for biomolecules;
wherein, in an initial plunger configuration, the aperture in the side wall is disposed between the first seal and the second seal to permit fluid to enter and leave the reaction chamber;
a tube disposed around the hollow plunger and defining at least a sample collection chamber and a sample washing chamber,
wherein the hollow plunger can be moved along the axis such that the reaction chamber is fluidically connected with either the sample collection chamber or the sample washing chamber depending on a position of the hollow plunger;
wherein when in a reaction configuration the aperture is blocked so as to seal the reaction chamber;
wherein the reaction chamber includes one or more ampules containing one or more reagents;
wherein the one or more reagents can be released from the one or more ampules in the reaction chamber when the apparatus is in the reaction configuration.