US 11,833,253 B1
Extended release pharmaceutical composition of Clozapine
Mayank Saxena, Ahmedabad (IN); Rikin Patel, Ahmedabad (IN); Piyush Kansagra, Ahmedabad (IN); Balvir Singh, Ahmedabad (IN); and Ashish Sehgal, Ahmedabad (IN)
Assigned to INTAS PHARMACEUTICALS LTD., Ahmedabad (IN)
Filed by INTAS PHARMACEUTICALS LTD., Ahmedabad (IN)
Filed on Oct. 17, 2022, as Appl. No. 17/967,244.
Application 17/967,244 is a continuation of application No. 16/334,115, granted, now 11,504,336, previously published as PCT/IB2017/055615, filed on Sep. 16, 2017.
Claims priority of application No. 201621031726 (IN), filed on Sep. 17, 2016.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/50 (2006.01); A61K 9/20 (2006.01); A61K 9/51 (2006.01); A61K 31/5513 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/38 (2006.01)
CPC A61K 9/5073 (2013.01) [A61K 9/2077 (2013.01); A61K 9/5015 (2013.01); A61K 9/5047 (2013.01); A61K 9/5192 (2013.01); A61K 31/5513 (2013.01)] 12 Claims
 
1. An extended release pharmaceutical composition of Clozapine in the form of multiparticulates comprising:
a) Granules, pellets, beads or spheroids comprising Clozapine,
b) Seal coating comprising hydrophilic polymer,
c) Acidic coating comprising acidic substance, and
d) Extended release coating comprising a water insoluble polymer and a water soluble polymer;
wherein the ratio of acidic substance in acidic coating to Clozapine is 0.5:1 to 1:1 by weight by weight (W/W), and Clozapine is not coated on sugar sphere.