US 11,833,108 B2
Terminal sterilization filtration closed lyophilization in a container
Mark Joseph Doty, Grayslake, IL (US); Christine L. Rebbeck, Lake Barrington, IL (US); Sydney Jean Cope, Chicago, IL (US); William Spencer Hurst, Burlington, WI (US); Grant Anthony Bomgaars, Kildeer, IL (US); Yuanpang Samuel Ding, Long Grove, IL (US); Thomas Edward Dudar, Palatine, IL (US); Ying-Cheng Lo, Long Grove, IL (US); Mark Edward Pasmore, Grayslake, IL (US); Michael Joseph Sadowski, Ringwood, IL (US); Anastasios Hristakos, Evanston, IL (US); Joseph Vincent Ranalletta, Greenville, SC (US); and Bernd Krause, Rangendingen (DE)
Assigned to BAXTER INTERNATIONAL INC., Deerfield, IL (US); and BAXTER HEALTHCARE SA, Glattpark (CH)
Appl. No. 16/631,017
Filed by BAXTER INTERNATIONAL INC., Deerfield, IL (US); and BAXTER HEALTHCARE SA, Glattpark (CH)
PCT Filed Jul. 12, 2018, PCT No. PCT/US2018/041790
§ 371(c)(1), (2) Date Jan. 14, 2020,
PCT Pub. No. WO2019/018195, PCT Pub. Date Jan. 24, 2019.
Claims priority of provisional application 62/533,515, filed on Jul. 17, 2017.
Prior Publication US 2020/0146931 A1, May 14, 2020
Int. Cl. A61J 1/10 (2006.01); A61J 1/20 (2006.01); A61J 1/14 (2023.01); A61L 2/00 (2006.01); F26B 5/06 (2006.01)
CPC A61J 1/10 (2013.01) [A61J 1/1443 (2013.01); A61J 1/1475 (2013.01); A61J 1/2082 (2015.05); A61J 1/2086 (2015.05); A61J 1/2093 (2013.01); A61L 2/0017 (2013.01); A61J 1/2024 (2015.05); A61L 2202/181 (2013.01); F26B 5/06 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A sterile solution product bag for lyophilizing, the product bag comprising:
a bladder;
a first stem having a first stem inlet end and a first stem outlet end, the first stem outlet end fluidly connected to the bladder and the first stem inlet end adapted to receive a liquid for introduction into the bladder;
a first filter disposed in-line with the first stem, the first filter having a first filter membrane, a first filter open end, and a first filter closed end, the first filter closed end disposed between the first stem inlet end and the first stem outlet end and the first filter open end disposed in proximity to the first stem inlet end, the first filter arranged to sterilize the liquid as it passes through the first filter and into the bladder;
a second stem having a second stem inlet end and a second stem outlet end, the second stem inlet end fluidly connected to the bladder and adapted to receive a vapor resulting from lyophilization of the liquid in the bladder;
a second filter disposed in-line with the second stem, the second filter having a second filter membrane, a second filter open end, and a second filter closed end, the second filter open end disposed in proximity to the second stem inlet end.