US 11,832,948 B2
Intraoperative monitoring of neuromuscular function with soft, tissue-mounted wireless devices
John A. Rogers, Wilmette, IL (US); Michel Kliot, Evanston, IL (US); Roozbeh Ghaffari, Cambridge, MA (US); and YuHao Liu, Urbana, IL (US)
Assigned to NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed on Dec. 21, 2021, as Appl. No. 17/557,392.
Application 17/557,392 is a continuation of application No. 16/969,649, granted, now 11,246,522, previously published as PCT/US2019/019166, filed on Feb. 22, 2019.
Claims priority of provisional application 62/634,440, filed on Feb. 23, 2018.
Prior Publication US 2022/0110564 A1, Apr. 14, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/24 (2021.01); A61B 5/296 (2021.01); A61B 5/398 (2021.01); A61B 5/25 (2021.01); A61B 5/00 (2006.01); A61N 1/04 (2006.01)
CPC A61B 5/24 (2021.01) [A61B 5/0004 (2013.01); A61B 5/25 (2021.01); A61B 5/296 (2021.01); A61B 5/398 (2021.01); A61B 5/742 (2013.01); A61N 1/0456 (2013.01); A61B 2562/164 (2013.01)] 72 Claims
OG exemplary drawing
 
1. A method of characterizing a neuromuscular property of a subject comprising:
providing a conformable device comprising:
a flexible or stretchable substrate; and
a sensor supported by said flexible or stretchable substrate; said sensor comprising a plurality of electrodes for measuring electric potentials of a tissue of said subject;
wherein said flexible or stretchable substrate and said sensor provide a net bending stiffness such that the device is capable of establishing conformal contact with a receiving surface of the tissue;
contacting said device with said receiving surface of the tissue, wherein said contacting results in said conformal contact of at least a portion of said device with said surface of the tissue; and
measuring a temporal profile of said electric potentials of the tissue with said plurality of electrodes; thereby characterizing said neuromuscular property, wherein said characterization of said neuromuscular property provides a real-time clinical metric.