| CPC H01J 49/0454 (2013.01) [H01J 49/165 (2013.01)] | 12 Claims |
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1. A system for automatically calculating an optimal value for at least one operational parameter of an acoustic droplet ejection (ADE) device, an open port interface (OPI), or an ion source device using a mass spectrometer, comprising:
an ADE device adapted to perform one or more ejections of a sample over time;
an OPI adapted to receive the one or more ejections over time at an inlet of an inner tube,
mix received ejections with a solvent to form a series of sample-solvent dilutions, and
transfer the series of dilutions to an outlet of the inner tube;
an ion source device adapted to receive the series of dilutions and ionize the series of dilutions, producing an ion beam;
a mass spectrometer adapted to receive the ion beam and mass analyze the ion beam over time, producing intensity versus time mass peaks corresponding to the one or more ejections; and
a processor in communication with the ADE device, the OPI, the ion source device, and the mass spectrometer that
for each value of a plurality of parameter values for at least one parameter of the ADE device, the OPI, or the ion source device, sets the at least one parameter to the each value, instructs the ADE device, the OPI, the ion source device, and the mass spectrometer to produce one or more intensity versus time mass peaks for the sample, and calculates a feature value for at least one feature of the one or more intensity versus time mass peaks, producing a plurality of feature values corresponding to the plurality of parameter values, and
calculates an optimal value for the at least one parameter from the plurality of feature values corresponding to the plurality of parameter values.
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