US 12,488,900 B2
Systems and methods for transitioning patient care from signal-based monitoring to risk-based monitoring
Dimitar V. Baronov, Weston, MA (US); Evan J. Butler, New Haven, CT (US); Jesse M. Lock, Winchester, MA (US); and Michael F. McManus, Pembroke, MA (US)
Assigned to Etiometry Inc., Boston, MA (US)
Filed by Etiometry Inc., Boston, MA (US)
Filed on Jun. 7, 2023, as Appl. No. 18/206,752.
Application 18/206,752 is a continuation of application No. 17/033,591, filed on Sep. 25, 2020, granted, now 11,676,730.
Application 17/033,591 is a continuation in part of application No. 16/113,486, filed on Aug. 27, 2018, granted, now 10,796,804, issued on Oct. 6, 2020.
Application 16/113,486 is a continuation of application No. 14/727,696, filed on Jun. 1, 2015, granted, now 10,062,456, issued on Aug. 28, 2018.
Application 14/727,696 is a continuation of application No. 13/826,441, filed on Mar. 14, 2013, abandoned.
Application 13/826,441 is a continuation in part of application No. 13/689,029, filed on Nov. 29, 2012, abandoned.
Application 13/826,441 is a continuation in part of application No. 13/328,411, filed on Dec. 16, 2011, abandoned.
Claims priority of provisional application 62/906,518, filed on Sep. 26, 2019.
Claims priority of provisional application 61/774,274, filed on Mar. 7, 2013.
Claims priority of provisional application 61/727,820, filed on Nov. 19, 2012.
Claims priority of provisional application 61/699,492, filed on Sep. 11, 2012.
Claims priority of provisional application 61/684,241, filed on Aug. 17, 2012.
Claims priority of provisional application 61/620,144, filed on Apr. 4, 2012.
Claims priority of provisional application 61/614,846, filed on Mar. 23, 2012.
Claims priority of provisional application 61/614,861, filed on Mar. 23, 2012.
Prior Publication US 2023/0317296 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G16H 50/30 (2018.01); G16H 50/20 (2018.01); G16H 50/50 (2018.01)
CPC G16H 50/30 (2018.01) [G16H 50/20 (2018.01); G16H 50/50 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A computer-based method of risk-based monitoring of a patient, the method comprising:
generating, by the computer, predicted probability density functions of internal state variables for a subsequent time step (tk+1), wherein the predicted probability density functions are calculated using posterior estimated probability density functions from a preceding time step (tk);
acquiring, by the computer at subsequent time step (tk+1), physiological data from a set of sensors connected with the patient;
generating a conditional likelihood kernel for the subsequent time step (tk+1), the conditional likelihood kernel comprising conditional probability density functions of the physiological data acquired at subsequent time step (tk+1) given the predicted probability density functions of internal state variables for subsequent time step (tk+1);
continuously estimating a risk that a particular bio-marker of the patient is abnormal, wherein the particular bio-marker comprises a hidden internal state variable, because it exceeds, by being either above or below, a corresponding pre-defined clinically significant value for that bio-marker, by:
generating, using Bayes theorem operating on (a) the conditional likelihood kernel and (b) predicted probability density functions of internal state variables for subsequent time step (tk+1), posterior probability density functions for the plurality of the internal state variables for the subsequent time step (tk+1); and
generating, for the particular bio-marker and based on the posterior probability density functions for the subsequent time step (tk+1), a probability that the particular bio-marker exceeds the corresponding pre-defined threshold for that particular bio-marker; and
generating, for display on a display device, a graphical depiction of the risk that the bio-marker is abnormal.