US 12,488,882 B2
System and method for alerting providers to ineffective or under effective treatments based on genetic efficacy testing results
Rob Todd, Doylestown, PA (US); Jerry Wrobel, Aurora, OH (US); and John Pigott, Slyvania, OH (US)
Assigned to Xact Laboratories, LLC, Twinsburg, OH (US)
Filed by Xact Laboratories, LLC, Twinsburg, OH (US)
Filed on Nov. 8, 2023, as Appl. No. 18/388,075.
Application 18/388,075 is a continuation of application No. 17/553,096, filed on Dec. 16, 2021.
Application 17/553,096 is a continuation of application No. 16/848,458, filed on Apr. 14, 2020, granted, now 11,227,685, issued on Jan. 18, 2022.
Application 16/848,458 is a continuation in part of application No. 16/674,189, filed on Nov. 5, 2019, granted, now 11,380,424, issued on Jul. 5, 2022.
Application 16/674,189 is a continuation in part of application No. 16/441,597, filed on Jun. 14, 2019, granted, now 11,527,331, issued on Dec. 13, 2022.
Claims priority of provisional application 62/773,424, filed on Nov. 30, 2018.
Claims priority of provisional application 62/685,479, filed on Jun. 15, 2018.
Prior Publication US 2024/0079120 A1, Mar. 7, 2024
Int. Cl. G16H 40/20 (2018.01); C12Q 1/6869 (2018.01); G06F 16/245 (2019.01); G06F 40/205 (2020.01); G06Q 10/10 (2023.01); G06Q 20/42 (2012.01); G06Q 30/016 (2023.01); G06Q 40/02 (2023.01); G06Q 40/08 (2012.01); G16B 35/20 (2019.01); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 70/40 (2018.01); H04L 9/40 (2022.01)
CPC G16H 40/20 (2018.01) [C12Q 1/6869 (2013.01); G06F 16/245 (2019.01); G06F 40/205 (2020.01); G06Q 10/10 (2013.01); G06Q 20/42 (2013.01); G06Q 30/016 (2013.01); G06Q 40/02 (2013.01); G06Q 40/08 (2013.01); G16B 35/20 (2019.02); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 70/40 (2018.01); H04L 63/0428 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A system for alerting a user to prescribed treatments likely to have reduced or no effectiveness due to genetic composition on a patient-specific basis, the system comprising:
an electronic network comprising:
healthcare affiliated nodes, said nodes including a healthcare provider system comprising electronic medical records data for patients treated by the healthcare provider, said electronic medical records data including data regarding patient identity and treatments prescribed by, or likely to be prescribed by, the healthcare provider to the patients and at least one pharmacy benefits manager system;
one or more databases comprising data regarding treatments known to have reduced or no efficacy in persons having particular genetic markers;
one or more genetic sequencing machines, each configured to accept genetic testing devices comprising genetic material for performing genetic testing in an automated fashion; and
one or more non-transitory electronic storage devices comprising software instructions, which when executed, configure one or more processors to, electronically and in an automated fashion:
receive orders for genetic testing from the healthcare provider system for at least some of the patients (“testing patients”), said orders comprising the patient identity data for the respective one of the testing patients;
in response to receiving said orders for genetic testing, operationally cause and control the automated assembly or modification of the genetic testing devices for the testing patients, including adding, removing, blocking, and/or unlocking wells of the genetic testing device to provide a patient-specific testing panel, and performance of the patient-specific genetic testing at the one or more genetic sequencing machines such that an order specific genetic testing device is generated for, and in accordance with, each of the received orders;
receive genetic testing results from the one or more genetic sequencing machines for testing patients;
generate, for each of the testing patients, a standardized file comprising standardized data indicating the genetic testing results from the one or more genetic sequencing machines for the respective one of the testing patients, each of said standardized files comprising structured data fields including the patient identity data for, and one or more genetic marker identifiers of, the respective one of the testing patients;
transmit the standardized files to the healthcare provider system for direct integration into the electronic medical records data;
electronically receive, for each of the testing patients, the patient identity data and data indicating the treatments prescribed to, or likely to be prescribed to, the testing patients (“treatment data”) from at least one of the healthcare affiliated nodes (“requesting node”) in a structured format;
query the one or more databases with the patient identity data and the treatment data to determine whether any of the treatments prescribed to, or likely to be prescribed to, the respective one of the testing patients is known to have reduced or no efficacy in persons having the same certain genetic markers as the respective one of the testing patients; and
automatically generate a standardized electronic alert for communication on the electronic network to one or more of the healthcare affiliated nodes, including the requesting node, said standardized electronic alert being interpretable by each of the healthcare affiliated nodes to indicate each of the treatments in the treatment data which are known to have reduced or no efficacy in persons having the same certain genetic markers as the patient as having reduced or no efficacy for the patient.